2 documents found, page 1 of 1
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pat...
Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J.; Marques, Xavier; Gomez-Murcia, Victoria; Deleau, Aude; Huin, Vincent; Hansen, Jan NAccumulating data support the role of tau pathology in cognitive decline in ageing and Alzheimer's disease, but underlying mechanisms remain ill-defined. Interestingly, ageing and Alzheimer's disease have been associated with an abnormal upregulation of adenosine A2A receptor (A2AR), a fine tuner of synaptic plasticity. However, the link between A2AR signalling and tau pathology has remained largely unexplored....
Beneficial effect of a selective adenosine A2A receptor antagonist in the APPsw...
Faivre, Emilie; Coelho, Joana E; Zornbach, Katja; Malik, Enas; Baqi, Younis; Schneider, Marion; Cellai, Lucrezia; Carvalho, Kevin; Sebda, ShéhérazadeConsumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease. While short-term treatment with A2AR antagonists have been shown to alleviate cognitive deficits in mouse models of amyloidogenesis, impact of a chronic and long-term treatment on the devel...