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Urban environment during pregnancy and lung function, wheezing, and asthma in s...

Abellan, A; Warembourg, C; Mensink-Bout, SM; Ambros, A; de Castro, M; Fossati, S; Guxens, M; Jaddoe, VW; Nieuwenhuijsen, MJ; Vrijheid, M; Santos, S

The urban environment during pregnancy may influence child's respiratory health, but scarce evidence exists on systematic evaluation of multiple urban exposures (e.g., air pollution, natural spaces, noise, built environment) on children's lung function, wheezing, and asthma development. We aimed to examine the association of the urban environment during pregnancy with lung function, preschool wheezing, and scho...


Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes:...

Fernandes, A; Avraam, D; Cadman, T; Dadvand, P; Guxens, M; Binter, A-C; Pinot de Moira, A; Nieuwenhuijsen, M; Duijts, L; Julvez, J; De Castro, M

Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European bi...


Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Ea...

Gonçalves Soares, A; Santos, S; Seyve, E; Nedelec, R; Puhakka, S; Eloranta, A-M; Mikkonen, S; Yuan, WL; Lawlor, DA; Heron, J; Vrijheid, M; Lepeule, J

Background: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (S...


Associations of green and blue space exposure in pregnancy with epigenetic gest...

Marques, I; Santos, S; Monasso, GS; Fossati, S; Vrijheid, M; Nieuwenhuijsen, M; Jaddoe, VWV; Felix, JF

Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these associations. In 1359 mother-newborn pairs from the population-based Generation R Study, we examined the associati...


Exposure to natural environments during pregnancy and birth outcomes in 11 euro...

Torres Toda, M; Avraam, D; James Cadman, T; Fossati, S; de Castro, M; Dedele, A; Donovan, G; Elhakeem, A; Estarlich, M; Fernandes, A; Gonçalves, R

Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, par...


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