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Reproductive factors, hormonal interventions, and gastric cancer risk in the St...

Song, M; Jayasekara, H; Pelucchi, C; Rabkin, CS; Johnson, KC; Hu, J; Palli, D; Ferraroni, M; Liao, LM; Bonzi, R; Zaridze, D; Maximovitch, D; Aragonés, N

Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations...


Mushroom consumption and risk of gastric cancer: a pooled analysis within the s...

Ba, DM; Ssentongo, P; Pelucchi, C; Negri, E; Palli, D; Ferraroni, M; Zhang, ZF; Yu, GP; Tsugane, S; Hidaka, A; Hamada, GS; Zaridze, D; Maximovich, D

Edible mushrooms have high concentrations of vitamins and minerals. They are considered ‘functional foods’ for their disease-prevention properties. Mushroom consumption may reduce the risk of gastric cancer, the fifth most common cancer worldwide. We investigated the association between mushroom consumption and gastric cancer risk in a pooled analysis within the Stomach Cancer Pooling (StoP) Project and in a me...


Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysi...

Collatuzzo, G; Pelucchi, C; Negri, E; Kogevinas, M; Huerta, JM; Vioque, J; de la Hera, MG; Tsugane, S; Hamada, GS; Hidaka, A; Zhang, ZF; Camargo, MC

The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for sleep duration and stress level in association with GC through multiple logistic regression...


The mediating role of combined lifestyle factors on the relationship between ed...

Alicandro, G; Bertuccio, P; Collatuzzo, G; Pelucchi, C; Bonzi, R; Liao, LM; Rabkin, CS; Sinha, R; Negri, E; Dalmartello, M; Zaridze, D; Maximovich, D

Background: The causal pathway between high education and reduced risk of gastric cancer (GC) has not been explained. The study aimed at evaluating the mediating role of lifestyle factors on the relationship between education and GC Methods: Ten studies with complete data on education and five lifestyle factors (smoking, alcohol drinking, fruit and vegetable intake, processed meat intake and salt consumption) w...


Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case...

Morais, S; Peleteiro, B; Araújo, N; Malekzadeh, R; Ye, W; Plymoth, A; Tsugane, S; Hidaka, A; Hamada, GS; López-Carrillo, L; Zaridze, D; Maximovich, D

Background: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection. We estimated the proportion of HpNGC, using different criteria to define infection status, and compared...


Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Poo...

Morais, S; Costa, A; Albuquerque, G; Araújo, N; Pelucchi, C; Rabkin, CS; Liao, LM; Sinha, R; Zhang, Z-F; Hu, J; Johnson, KC; Palli, D; Ferraroni, M

Purpose: Previous studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between total salt or added salt and gastric cancer are less consistent and vary with the exposure considered. This study aimed to quantify the association between dietary salt exposure and gastric cancer, using an individual participant data meta-analysis of studies pa...


The association between diabetes and gastric cancer: results from the Stomach C...

Dabo, B; Pelucchi, C; Rota, M; Jain, H; Bertuccio, P; Bonzi, R; Palli, D; Ferraroni, M; Zhang, Z-F; Sanchez-Anguiano, A; Thi-Hai, Pham, Y

Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of mor...


Coffee consumption and gastric cancer: A pooled analysis from the Stomach cance...

Martimianaki, G; Bertuccio, P; Alicandro, G; Pelucchi, C; Bravi, F; Carioli, G; Bonzi, R; Rabkin, CS; Liao, LM; Sinha, R; Johnson, K; Hu, J; Palli, D

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals ...


Sex differences in the prevalence of Helicobacter pylori infection: an individu...

Ferro, A; Morais, S; Pelucchi, C; Dierssen-Sotos, T; Martín, V; López-Carrillo, L; Malekzadeh, R; Tsugane, S; Hamada, GS; Hidaka, A

Background Helicobacter pylori (H. pylori) infection is more frequent among men, though the magnitude of the association might be inaccurate due to potential misclassification of lifetime infection and publication bias. Moreover, infection is common, and most studies are cross-sectional. Thus, prevalence ratios (PRs) may be easier to interpret than odds ratios (ORs). Aim The aim of this study was to quantify th...


Smoking and Helicobacter pylori infection: an individual participant pooled ana...

Ferro, A; Morais, S; Pelucchi, C; Aragonés, N; Kogevinas, M; López-Carrillo, L; Malekzadeh, R; Tsugane, S; Hamada, GS; Hidaka, A; Hernández-Ramírez, RU

Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using ...


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