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Biomarkers for tuberculosis: the case for lipoarabinomannan

Correia-Neves, M; Fröberg, Gabrielle; Korshun, Liudmyla; Viegas, Sofia; Vaz, Paula; Ramanlal, Nehaben; Bruchfeld, Judith; Hamasur, Beston

Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis inf...

Date: 2019   |   Origin: RepositóriUM - Universidade do Minho
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Lipoarabinomannan, and its related glycolipids, induce divergent and opposing i...

Källenius, Gunilla; Neves, Margarida Correia; Buteme, Helen; Hamasur, Beston

Exposure to Mycobacterium tuberculosis (Mtb) may lead to active or latent tuberculosis, or clearance of Mtb, depending essentially on the quality of the host's immune response. This response is initiated through the interaction of Mtb cell wall surface components, mostly glycolipids, with cells of the innate immune system, particularly macrophages (Mfs) and dendritic cells (DCs). The way Mfs and DC alter their ...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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