3 documents found, page 1 of 1
New steroidal aromatase inhibitors: biological effects in hormone-dependent bre...
Sobral, Ana Filipa; Amaral, Cristina; Varela, Carla; Tavares, Elisiário; Roleira, Fernanda; Correia-Da-Silva, Georgina; Teixeira, Natércia; Campos, SaulAromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effect...
Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against...
Serafim, Teresa L.; Carvalho, Filipa S.; Marques, Maria P. M.; Calheiros, Rita; Silva, Tiago; Garrido, Jorge; Milhazes, Nuno; Borges, FernandaIn the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were initially evaluated: caffeic acid (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), ferulic acid (FA), hexyl ferulate (HF), and feruloylhexylamide (HFA). Cell proliferation, cell cycle progression, and apoptotic signaling wer...
Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against...
Serafim, Teresa L.; Carvalho, Filipa S.; Marques, Maria P. M.; Calheiros, Rita; Silva, Tiago; Garrido, J.M.P.J.; Milhazes, Nuno; Borges, FernandaIn the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were initially evaluated: caffeic acid (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), ferulic acid (FA), hexyl ferulate (HF), and feruloylhexylamide (HFA). Cell proliferation, cell cycle progression, and apoptotic signaling wer...