3 documents found, page 1 of 1
The recombinant plant Bauhinia bauhinioides elastase inhibitor reduces rat thro...
Oliveira, Cleide; Valois, Mayara Vioto; Ottaiano, Tatiana Fontes; Miranda, Antonio; Hansen, Daiane; Sampaio, Misako Uemura; Oliva, Maria Luiza VilelaMade available in DSpace on 2022-04-29T08:30:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; The anti-inflammatory effects of the plant protease inhibitor BbCI (Bauhinia bauhinioides cruzipain inhibitor), which blocks elastase, cathepsin G, and L, and proteinase 3 has been demonstrated. Here, we investigated the recombinant rBbCI-His(6) (containing a histidine tail) in an experimental venous th...
Pharmaceutical properties of 'sucupira' (Pterodon spp.)
Hansen, Daiane; Haraguchi, Mitsue; Alonso, AntonioThe plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolite...
Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor
Hansen, Daiane; Macedo-Ribeiro, Sandra; Veríssimo, Paula; Yoo Im, Sonia; Sampaio, Misako Uemura; Oliva, Maria Luiza VilelaBauhinia bauhinioides Cruzipain Inhibitor (BbCI) is a cysteine protease inhibitor highly homologous to plant Kunitz-type inhibitors. However, in contrast to classical Kunitz family inhibitors it lacks cysteine residues and therefore disulfide bridges. BbCI is also distinct in the ability to inactivate enzymes belonging to two different classes, cysteine and serine proteases. Besides inhibiting the cysteine prot...