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Weighted single-step GWAS and gene network analysis reveal new candidate genes ...
Marques, Daniele B. D.; Bastiaansen, John W. M.; Broekhuijse, Marleen L. W. J.; Lopes, Marcos S.; Knol, Egbert F.; Harlizius, BarbaraIn recent years, there has been increased interest in the study of the molecular processes that affect semen traits. In this study, our aim was to identify quantitative trait loci (QTL) regions associated with four semen traits (motility, progressive motility, number of sperm cells per ejaculate and total morphological defects) in two commercial pig lines (L1: Large White type and L2: Landrace type). Since the ...
Linkage disequilibrium patterns and persistence of phase in purebred and crossb...
Veroneze, Renata; Bastiaansen, John WM; Knol, Egbert F; Guimarães, Simone EF; Silva, Fabyano F; Harlizius, Barbara; Lopes, Marcos S; Lopes, Paulo SGenomic selection and genomic wide association studies are widely used methods that aim to exploit the linkage disequilibrium (LD) between markers and quantitative trait loci (QTL). Securing a sufficiently large set of genotypes and phenotypes can be a limiting factor that may be overcome by combining data from multiple breeds or using crossbred information. However, the estimated effect of a marker in one bree...