3 documents found, page 1 of 1
Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate ...
Hartmann, Diego O.; Shimizu, Karina; Rothkegel, Maika; Petkovic, Marija; Ferraz, Ricardo; Petrovski, Zeljko; Branco, Luís C.; Lopes, José N. CanongiaAspergillus species are the primary cause of invasive aspergillosis, which afflicts hundreds of thousands of patients yearly, with high mortality rates. Amphotericin B is considered the gold standard in antifungal drug therapy, due to its broad-spectrum activity and rarely reported resistance. However, low solubility and permeability, as well as considerable toxicity, challenge its administration. Lipid formula...
Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanc...
Alves, Paula C.; Hartmann, Diego O.; Núñez, Oscar; Martins, Isabel; Gomes, Teresa L.; Garcia, Helga; Galceran, Maria Teresa; Hampson, RichardThe inherent potential of filamentous fungi, especially of Ascomycota, for producing diverse bioactive metabolites remains largely silent under standard laboratory culture conditions. Innumerable strategies have been described to trigger their production, one of the simplest being manipulation of the growth media composition. Supplementing media with ionic liquids surprisingly enhanced the diversity of extracel...
Surfactants as microbicides and contraceptive agents: a systematic in vitro study
Vieira, Otília V.; Hartmann, Diego O.; Cardoso, Carla M. P.; Oberdoerfer, Daniel; Baptista, Marta; Santos, Manuel A. S.; Almeida, LuisBackground: The urgent need for cheap and easy-to-use protection against both unwanted pregnancies and sexually transmitted diseases has stimulated considerable interest in the use of surfactants as microbicides, anti-viral, and contraceptive agents in recent years. In the present study we report a systematic in vitro evaluation of the microbicidal, anti- viral and contraceptive potential of cationic, anionic, ...