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Management of patients at very high risk of osteoporotic fractures through sequ...

Curtis, Elizabeth M.; Reginster, Jean-Yves; Al-Daghri, Nasser; Biver, Emmanuel; Brandi, Maria Luisa; Cavalier, Etienne; Hadji, Peyman; Halbout, Philippe

Osteoporosis care has evolved markedly over the last 50 years, such that there are now an established clinical definition, validated methods of fracture risk assessment and a range of effective pharmacological agents. Currently, bone-forming (anabolic) agents, in many countries, are used in those patients who have continued to lose bone mineral density (BMD), patients with multiple subsequent fractures or those...


Role of vitamin D supplementation in the management of musculoskeletal diseases...

Chevalley, Thierry; Brandi, Maria Luisa; Cashman, Kevin D.; Cavalier, Etienne; Harvey, Nicholas C.; Maggi, Stefania; Cooper, Cyrus; Al-Daghri, Nasser

Vitamin D is a key component for optimal growth and for calcium-phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (c...


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