16 documents found, page 1 of 2
Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and pr...
Gonçalves, Samuel M.; Antunes, Daniela; Leite, Luis; Mercier, Toine; Horst, Rob Ter; Vieira, Joana; Espada, Eduardo; Pinho Vaz, Carlos; Branca, RosaActivation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role...
PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Trans...
Campos, Cláudia F.; Leite, Luís; Pereira, Paulo; Vaz, Carlos Pinho; Branca, Rosa; Campilho, Fernando; Freitas, Fátima; Ligeiro, Dário; Marques, AntónioBackground: Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Although pentraxin-3 (PTX3) has been previously described to bind both human and murine CMV and mediate several host antiviral mechanisms, whether genetic variation in the PTX3 lo...
PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell trans...
Campos, Cláudia F.; Leite, Luís; Pereira, Paulo; Vaz, Carlos Pinho; Branca, Rosa; Campilho, Fernando; Freitas, Fátima; Ligeiro, Dário; Marques, AntónioBackground: Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Although pentraxin-3 (PTX3) has been previously described to bind both human and murine CMV and mediate several host antiviral mechanisms, whether genetic variation in the PTX3 lo...
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antif...
Cunha, Cristina; Gonçalves, Samuel M.; Duarte-Oliveira, Claudio; Leite, Luis; Lagrou, Katrien; Marques, António; Lupianez, Carmen B.; Mesquita, Inês[Excerpt] To the Editor: Proinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection.[...]
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antif...
Cunha, Cristina; Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Leite, Luís; Lagrou, Katrien; Marques, António; Lupiañez, Carmen B.; Mesquita, InêsProinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection. A central negative regulator of inflammatory responses is IL-10, an immunosuppressive cytokine with a wide variety of functions across multiple cell types. Although the role of IL-10 ...
Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Ly...
Brito, Margarida Dantas; Campilho, Fernando; Branca, Rosa; Vaz, Carlos; Roncon, Susana; Campos, AntónioIntroduction: Diffuse large B-cell lymphoma can be cured in 60% – 70% of patients. Autologous stem cell transplantation is the standard treatment for relapsed disease. This high-intensity treatment after first complete remission in patients with high International Prognostic Index remains controversial and was performed in our department during some years. Material and Methods: Retrospective study, review of cl...
Outcomes of allogeneic stem cell transplantation among patients with acute myel...
Bezerra de-Mello, Ramon Andrade; Pinho-Vaz, Carlos; Branca, Rosa; Campilho, Fernando; Rosales, Maria; Roncon, Susana; Campos-Junior, AntonioIntroduction: Allogeneic hematopoietic stem cell transplantation (ASCT) represents a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML). We report the outcome of relapsed/refractory AML patients treated with ASCT.Method: A retrospective cohort from 1994 to 2013 that included 61 patients with diagnosis of relapsed/refractory AML. Outcomes of interest were transpla...
Anemia Ferripriva Resistente à Terapêutica com Ferro Oral na Encruzilhada de do...
Silva, Armandina; Sarmento, Alzira; Costa, Elísio; Branca, Rosa; Barbot, JoséA resistência à terapêutica com ferro oral de uma anemia ferripriva obriga à consideração de um âmbito relativamente alargado de factores etiológicos. Alguns desses factores podem ter um carácter silencioso» traduzindo-se na ausência de manifestações ou na presença de sinais e/ou sintomas inespecíficos, frequentemente não valorizados. A intoxicação pelo chumbo e a doença celíaca são duas dessas situações, cuja ...
The identification of multiple thrombophilic risk factors in an infant with cer...
Neves, Joana; Costa, Elísio; Branca, Rosa; Carrilho, Inês; Barbot, José; Barbot, ClaraLa frecuencia del accidente vascular cerebral (AVC) neonatal ha aumentado de manera significativa en los últimos años. Ello puede deberse no tanto a un aumento real del número de casos, como a una mayor certeza en su diagnóstico. Actualmente, su incidencia se ha calculado en un caso por cada 4.000 nacimientos. Caso clínico. Lactante con AVC en el área de la arteria cerebral media izquierda, del cual se disponía...
Coexistence of congenital red cell pyruvate kinase and band 3 deficiency
Branca, Rosa; Costa, Elísio; Rocha, Susana; Coelho, Henrique; Quintanilha, Alexandre; Cabeda, José; Santos-Silva, Alice; Barbot, JoséThe authors report the case of a 9-year-old Caucasian girl, born in northern Portugal, with chronic nonspherocytic haemolytic anaemia and without family history of anaemia. The aethiological study of this anaemia revealed pyruvate kinase deficiency (PKD), because of two previously described mutations (426Arg fi Trp and 510Arg fi Gln). Since the blood smear revealed features not fully compatible with PKD diagnos...