2 documents found, page 1 of 1
Bioengineered hierarchical bonelike compartmentalized microconstructs using nan...
Bjørge, Isabel M.; Sousa, Bárbara M. de; Patrício, Sónia G.; Silva, Ana Sofia; Nogueira, Liebert P.; Santos, Lúcia F.; Vieira, Sandra I.Fabrication of vascularized large-scale constructs for regenerative medicine remains elusive since most strategies rely solely on cell self-organization or overly control cell positioning, failing to address nutrient diffusion limitations. We propose a modular and hierarchical tissue-engineering strategy to produce bonelike tissues carrying signals to promote prevascularization. In these 3D systems, disc-shaped...
In vitro biological response of human osteoblasts in 3D chitosan sponges with c...
Sukul, Mousumi; Sahariah, Priyanka; Lauzon, Hélène L.; Borges, João; Másson, Már; Mano, João F.; Haugen, Håvard J.; Reseland, Janne E.We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure, irrespective of the DDA (58, 73, 82, 88, and 91 %) and Mw (749, 54...