Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four...
The stability of slender columns is a topic that has been dealt with in research and practice for many years. The importance of this topic also increases with the possibility of using non-linear modeling approaches to determine the stability and with the increasingly complex safety formats. In order to show the complexity and the variability associated with the non-linear models, two previous contributions disc...
Non-linear finite element analyses have intrinsic model and user factors that influence the results of the analyses. However, non-linear finite element analysis can provide a tool to assess safety using realistic descriptions of material behaviour with actual material properties. A realistic estimation of the existing safety and capacity of slender column elements can be achieved by means of "true" material pro...