25 documents found, page 1 of 3
Veneno de Bothrops erythromelas ( Amaral, 1923 ) induz apoptose em células epit...
Sousa, Fabíola Carine Monteiro de; Jorge, Antônio Rafael Coelho; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Torres, Alba Fabíola CostaBothrops erythromelas is responsible for a large number of snakebite incidents in Northeastern Brazil. Previously, we showed the effects of whole B. erythromelas venom in an isolated kidney model. To continue the study with B. erythromelas venom, the present work aims to study the effects of this venom on MDCK tubular epithelial cells and assess gene expression involved in kidney injury, aiming at elucidating t...
Buck (Capra hircus) genes encode new members of the spermadhesin family
Melo, Luciana Magalhães; Teixeira, Dárcio Ítalo Alves; Havt, Alexandre; Cunha, Maranguape Silva da; Rádis-Baptista, GandhiSpermadhesins are the major proteins of the boar seminal plasma and form a group of polypeptides probably involved in different steps of reproduction. In previous work, a member of the spermadhesin family from buck (Capra hircus ) seminal plasma, named BSFP, was isolated and characterized by mass spectrometry and the N-terminal was sequenced. This work aimed to found and characterize the BSFP gene and detect it...
Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root ext...
Alves, Natacha Teresa Queiroz; Ximenes, Rafael M.; Jorge, Roberta J. B.; Silveira, J. A. M.; Santos, J. V. A.; Rodrigues, F. A. P.; Costa, P. H. S.Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic ...
Etiology and severity of diarrheal diseases in infants at the semiarid region o...
Lima, Aldo A. M.; Oliveira, Domingos B.; Quetz, Josiane S.; Havt, Alexandre; Prata, Mara M. G.; Lima, Ila F. N.; Soares, Alberto M.; Q. Filho, JoséBackground Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemio...
Intestinal cell migration damage induced by enteropathogenic Escherichia coli s...
Cavalcante, Paloma A.; Prata, M. M. G.; Medeiros, Pedro Henrique Quintela Soares; Silva, A.V. Alves da; Quetz, Josiane S.Epithelial cell migration is an essential response to enteric pathogens such as enteropathogenic Escherichia coli (EPEC). This study aimed to investigate the effects of EPEC infection on intestinal epithelial cell migration in vitro, as well as the involvement of type III secretion system (T3SS) and Rho GTPases. Crypt intestinal epithelial cells (IEC-6) were infected with EPEC strains (E2348/69, DescF, and the ...
Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ...
Farias, V. X.; Uchoa, P.N.; Aquino, Camila P.; Britto, L.R.G.; Fonteles, Manasses Claudino; Leal-Cardoso, José Henrique; Silva-Alves, Kerly Shamyra daThe transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8, and 12 weeks; 65 mg/kg; ip) diabetic rats (DB) and age-matched euglycemic (E) rats were used for the analysi...
Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulf...
Rodrigues, Francisco Adelvane de Paulo; Santos, Alan Diego da Conceição; Medeiros, Pedro Henrique Quintela Soares de; Prata, Mara de Moura GondimAcute kidney injury (AKI) and metabolic dysfunction are critical complications in sepsis syndrome; however, their pathophysiological mechanisms remain poorly understood. Therefore, we evaluated whether the pharmacological properties of 6-gingerol (6G) and 10-gingerol (10G) could modulate AKI and metabolic disruption in a rat model of sepsis (faecal peritonitis). Animals from the sham and AKI groups were intrape...
Escherichia coli and Salmonella ser. Saintpaul natural co-infection in a free-l...
Bezerra, W. G. A.; Horn, R. V.; Silva, I. N. G.; Siqueira, R. A. S.; Lucena, R.B.; Havt, Alexandre; Medeiros, P. H. Q. S.; Maciel, W. C.This study reports a co-infection of Escherichia coli and Salmonella in a free-living ruddy ground dove (Columbina talpacoti) received at the Laboratory of Ornithological Studies of the State University of Ceará, Brazil. The bird presented diarrhea, leg paralysis and anorexia, and died shortly after. Necropsy was then performed and samples from lung, kidney, liver and intestine were collected for microbiologica...
Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interac...
Chagas Vinhote, Juliana Freire; Lima, Danya Bandeira; Pessoa Bezerra de Menezes, Ramon Roseo Paula; Mello, Clarissa PerdigaoMade available in DSpace on 2018-11-28T21:36:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); FUNCAP; Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp ve...
Epidemiology of enteroaggregative Escherichia coli infections and associated ou...
Rogawski, Elizabeth T.; Guerrant, Richard L.; Havt, Alexandre; Lima, Ila F. N.; Medeiros, Pedro H. Q. S.; Seidman, Jessica C.; McCormick, Benjamin J. J.Background Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their associations with environmental enteropathy biomarkers and growth outcomes over the first two years of life in eight...