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Comprehensive molecular landscape of cetuximab resistance in head and neck canc...

Gomes, Izabela N. F.; Silva-Oliveira, Renato J. da; Silva, Luciane Sussuchi da; Martinho, Olga; Evangelista, Adriane F.; Helvoort Lengert, André van

Cetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of cetuximab response are known for HNSCC. Herein, we address the molecular mechanisms underlying cetuximab resistance in an in vitro model. We established a cetuximab resistant model (FaDu), using increased cetuximab concentrations for more than eigh...

Date: 2022   |   Origin: RepositóriUM - Universidade do Minho
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