3 documents found, page 1 of 1
Polymorphisms within autophagy-related genes as susceptibility biomarkers for m...
Clavero, Esther; Sanchez-Maldonado, José Manuel; Macauda, Angelica; Ter Horst, Rob; Marques, Maria Belém Sousa Sampaio; Jurczyszyn, ArturMultiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promot...
Identification of miRSNPs associated with the risk of multiple myeloma
Macauda, Angelica; Calvetti, Diego; Maccari, Giuseppe; Hemminki, Kari; Försti, Asta; Goldschmidt, Hartmut; Weinhold, Niels; Houlston, RichardMultiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility ...
Impact of polymorphic variation at 7p15.3, 3p22.1 and 2p23.3 loci on risk of mu...
Reis, R. M.; Martino, Alessandro; Campa, Daniele; Jamroziak, Krzysztof; Sainz, Juan; Buda, Gabriele; García-Sanz, Ramón; Lesueur, Fabienne