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Aquaporins Transcripts with Potential Prognostic Value in Pancreatic Cancer

Lopes, Paula Alexandra; Fonseca, Elisabete; Vieira Da Silva, Inês; Vigia, Emanuel; Paulino, Jorge; Soveral, Graça

Funding Information: This research was funded by the Fundação para a Ciência e a Tecnologia (FCT, Lisbon, Portugal) through the grant PTDC/BTM-SAL/28977/2017 to G.S., and projects UIDB/04138/2020, UIDP/04138/2020, and 2022.06601.PTDC to iMed.ULisboa, project UIDB/00276/2020 to CIISA, and project LA/P/0059/2020 to AL4AnimalS. It was also financially supported by FCT through the FCT Stimulus of Scientific Employm...


Impact of Chlorella vulgaris as feed ingredient and carbohydrases on the health...

Coelho, Diogo; Alfaia, Cristina; Lopes, Paula Alexandra; Pestana, José M.; Costa, Monica M.; Pinto, Rui M.; Almeida, Joao M.; Moreira, Olga

The implication of high dietary level of Chlorella vulgaris, individually and supplemented with two carbohydrase mixtures, on pigs' health and liver metabolism was assessed in this study. Forty crossbred (Large White × Landrace sows crossed with Pietrain boars) entire male pigs were randomly allocated to the following feeding treatments (n = 10): cereal-soybean meal basal diet (control); basal diet with 5% C. v...


Combined efects of dietary Laminaria digitata with alginate lyase on plasma met...

Costa, Mónica; Lopes, Paula Alexandra; Assunção, JMP; Alfaia, Cristina; Coelho, Diogo; Mourato, Miguel; Pinto, Rui; Lordelo, Maria; Prates, JAM

ABSTRACT - Background: The Laminaria digitata is an abundant macroalga and a sustainable feedstock for poultry nutrition. L. digitata is a good source of essential amino acids, carbohydrates and vitamins, including A, D, E, and K, as well as triacylglycerols and minerals, in particular iron and calcium. However, the few studies available in the literature with broilers document the application of this macroalga...


Combined effects of dietary Laminaria digitata with alginate lyase on plasma me...

Costa, Mónica Mendes; Lopes, Paula Alexandra; Assunção, José Miguel Pestana; Alfaia, Cristina; Coelho, Diogo; Mourato, Miguel; Pinto, Rui Manuel

Background: The Laminaria digitata is an abundant macroalga and a sustainable feedstock for poultry nutrition. L. digitata is a good source of essential amino acids, carbohydrates and vitamins, including A, D, E, and K, as well as triacylglycerols and minerals, in particular iron and calcium. However, the few studies available in the literature with broilers document the application of this macroalga as a dieta...


Effects of Chlorella vulgaris as a feed ingredient on the quality and nutrition...

Martins, Cátia Falcão; Pestana, José M.; Alfaia, Cristina; Costa, Mónica; Ribeiro, D. M.; Coelho, Diogo; Lopes, Paula Alexandra; Almeida, André

Chlorella vulgaris (CH) is usually considered a feed supplement in pig nutrition, and its use as an ingredient is poorly studied. Among many interesting characteristics, this microalga has high protein levels and can be a putative alternative for soybean meal. Our aim was to study the effect of a 5% CH incorporation in the diet, individually or combined with two carbohydrases, on meat quality traits and nutriti...


Effect of dietary inclusion of Spirulina on production performance, nutrient di...

Martins, Cátia F.; Assunção, José Pestana; Santos, David M. Ribeiro; Madeira, Marta Sofia Morgado; Alfaia, Cristina Maria; Lopes, Paula Alexandra

The effect of Spirulina (Arthrospira platensis), individually or in combination with two commercial carbohydrases, in piglet diets was assessed on growth performance, nutrient digestibility and meat quality traits. Forty post-weaned male piglets from Large White × Landrace sows crossed with Pietrain boars with an initial live weight of 12.0 ± 0.89 kg were used. Piglets were assigned to one of four dietary treat...


Influence of dietary supplementation with an amino acid mixture on inflammatory...

Prates, José A.M; Freire, João; Almeida, André; Martins, Cátia Falcão; Ribeiro, David M.; Osorio, Hugo; Pinho, Mário; Lopes, Paula Alexandra

In order to investigate the effect of a dietary amino acid mixture supplementation in lipopolysaccharide (LPS)-challenged weaned piglets, twenty-seven 28-day-old (8.2 ± 1.0 kg) newly weaned piglets were randomly allocated to one of three experimental treatments for five weeks. Diet 1: a CTRL treatment. Diet 2: an LPS treatment, where piglets were intraperitoneally administered LPS (25 μg/kg) on day 7. Diet 3: a...


Influence of dyslipidemia and smoking on redox markers in humans: a critical study

Lopes, Paula Alexandra; Rodrigues, Olívia Roos; Napoleão, Patrícia; Pavão, Maria Leonor; Nève, Jean; Santos, Maria Cristina; Viegas-Crespo, Ana Maria

Na actualidade, é consensual que os processos oxidativos desempenham um papel importante no aparecimento e progressão de inúmeras doenças. O conhecimento do comportamento, dos parâmetros do balanço redox, poderá surtir efeito na prevenção da ocorrência de tais patologias. OBJECTIVOS: o presente estudo numa perspectiva pioneira para uma população portuguesa (a de Lisboa) visa caracterizar a variação de parâmetro...


Blood antioxidant markers and elemental levels in Azorean patients with coronar...

Ferin, Rita; Napoleão, Patrícia; Gomes, Carla; Castro, Ana Rita; Lopes, Paula Alexandra; Martins, Dinis; Santos, Maria Cristina

Atherosclerosis (ATH) and related vascular diseases are the first cause of morbidity and mortality in Portugal, including the Azores’ Archipelago. The oxidation of low density lipoproteins (LDL) is considered to be an important event in the development of the disease. Accordingly, by preventing LDL oxidation, antioxidants can possibly reduce the risk or the progression of ATH. Essential trace elements as Cu, Se...


Blood trace element levels in patients with stabilized atherosclerosis

Viegas-Crespo, Ana Maria; Napoleão, Patrícia; Lopes, Paula Alexandra; Santos, Maria Cristina; Pavão, Maria Leonor; Pinheiro, Teresa

Cardiovascular diseases remain the leading cause of mortality in Western populations. Dislipidemia, hypertension, diabetes, obesity and tobacco consumption are the main risk factors for atherosclerosis and its thrombotic complications. However, these factors alone cannot account for all of the deaths caused by vascular pathologies. The possible interaction of some trace element levels with atherogenic diseases ...


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