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Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Rego De Sousa, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, MargaridaMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Intraductal Carcinoma Predicts Poor Response to Neoadjuvant Therapy in High-ris...
Bernardino, Rui; Yin, Leyi B.; Lajkosz, Katherine; Winquist, Eric; Cockburn, Jessica G.; Jenjitranant, Pocharapong; Veloso, Rosette; ÓConnell, ClarePublisher Copyright: © 2025 The Author(s); Background and objective: High-risk localized prostate cancer (PCa) patients may require neoadjuvant treatment (androgen deprivation therapy [ADT] plus abiraterone with or without taxane-based chemotherapy) before radical prostatectomy (RP). Intraductal carcinoma of the prostate (IDC) is an aggressive histological variant of prostate adenocarcinoma. This study aims to ...
Multiple Myeloma Laboratory Diagnostics Made Simple
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioPublisher Copyright: © 2025 by the authors.; Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventiona...
Profiling of urinary extracellular vesicle protein signatures from patients wit...
Bernardino, Rui; Carvalho, Ana Sofia; Hall, Michael J.; Alves, Liliana; Leão, Ricardo; Sayyid, Rashid; Pereira, Hermínia; Beck, Hans ChristianFunding Information: The project is funded by Liga Portuguesa Contra o Cancro \u2013 Terry Fox Grant. R.M. is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (CEEC position, DOI: https://doi.org/10.54499/CEECIND/03906/2017/CP1421/CT0004 ). A.S.C. is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (DOI: https://doi.org/10.54499/DL57/2016/CP1457/CT0013 ). R.B is supported by ...
Engaging European society at the forefront of cancer research and care
Baumann, Michael; Celis, Julio; Ringborg, Ulrik; Heitor, Manuel; Berns, Anton; Albreht, Tit; Arabadjiev, Jeliazko; Boutros, Michael; Brandenburg, MarioFunding Information: Finally, Dr Garralda highlighted progress made by Cancer Core Europe (CCE), an independent consortium of major cancer centres in Europe that have worked together to create a multi‐site European Cancer Institute, where joint translation and clinical research is performed, with a special focus on next‐generation clinical trials and precision medicine. The creation of large, shared databases t...
Extracellular vesicle proteome in prostate cancer
Bernardino, Rui Miguel Marques; Leão, Ricardo; Henrique, Rui; Pinheiro, Luis Campos; Kumar, Prashant; Suravajhala, Prashanth; Beck, Hans ChristianFunding Information: Funding: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER ...
Can epigenetic and inflammatory biomarkers identify clinically aggressive prost...
Santos, Pedro Bargão; Patel, Hitendra; Henrique, Rui; Félix, AnaProstate cancer (PCa) is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and mortality. It emerges through the acquisition of genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications and microRNA deregulation. These generate heritable transformations in the expression of genes but do not change the DNA sequence. Alteratio...
Analysis of epigenetic alterations in homologous recombination dna repair genes...
André, Saudade; Nunes, Sandra P.; Silva, Fernanda; Henrique, Rui; Félix, Ana; Jerónimo, CarmenBackground: Male breast cancer (BC) is a distinct neoplasm with low but rising incidence, frequently diagnosed as advanced stage disease. Considering the relevance of altered homologous recombination repair (HRR) in male BC, we aimed to explore the biomarker potential of aberrant promoter methylation of ATM, BRCA1, PALB2, RAD51B, and XRCC3. Methods: Formalin-fixed paraffin-embedded (FFPE) tissue samples from 12...