14 documents found, page 1 of 2
Update on Generalized Pustular Psoriasis.
Torres, Tiago; Antunes, Joana; Tavares Bello, Rui; Varela, Paulo; Henrique, Martinha; Marques Pinto, Gabriela; Figueiredo, Américo; Correia, OsvaldoGeneralized pustular psoriasis (GPP) is a rare but severe inflammatory skin disease characterized by the eruption of widespread sterile pustules, often accompanied by systemic inflammation. Although GPP can coexist with plaque psoriasis, it is increasingly recognized as a distinct entity with unique clinicopathological, immunologic, and genetic features. The dysregulated IL-36 pathway, including mutations in th...
Management of Psoriasis by Family Physicians: Referral Algorithm and Shared Man...
Torres, Tiago; Henrique, Martinha; Oliveira, Hugo; Rodrigues, Madalena; Ferreira, Paulo; Morais, Paulo; Alves, Sérgio; Lopes, Tiago CastroIntroduction: The implementation of models capable of improving referral quality, limiting the growth of waiting lists in hospitals, and ensuring the best possible treatment and follow-up of the psoriatic patient is of the utmost importance.Material and Methods: A panel of Family Physicians and Dermatologists discussed and created a simple and effective algorithm of referral for patients with psoriasis.Results:...
Abordagem do Doente com Psoríase pela Medicina Geral e Familiar: Algoritmo de R...
T, Torres; Henrique, Martinha; Oliveira, Hugo; Rodrigues, Madalena; Ferreira, Paulo; Morais, Paulo; Alves, Sérgio; Lopes, Tiago Castro; Cernadas, RuiIntroduction: The implementation of models capable of improving referral quality, limiting the growth of waiting lists in hospitals, and ensuring the best possible treatment and follow-up of the psoriatic patient is of the utmost importance. Material and methods: A panel of Family Physicians and Dermatologists discussed and created a simple and effective algorithm of referral for patients with psoriasis. Result...
Insights into CANDLE Syndrome
Kieselová, Katarina; Santiago, Felicidade; Henrique, MartinhaChronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction. This review chronicles the recognition of CANDLE syndrome, the developments in the understanding of the pathomechanism, genetic background, and the emerging therapeut...
Cutaneous Lesions as the First Manifestation of Multiple Myeloma: Two Case Reports
Kieselová, Katarína; Santiago, Felicidade; Ramos, Sofia; Cunha, Maria Fernanda; Henrique, MartinhaMultiple myeloma is a proliferative clonal disorder of plasma cells. The clinical presentation is highly variable, with recurrent infections, anemia, renal insufficiency or bone pain from osteolytic lesions as the main initial manifestations. Skin manifestations are unusual and mostly unspecific. We describe two patients with cutaneous lesions as the first sign of this hematologic malignancy: nodular deposits o...
Trichoscopy as a Clue to the Diagnosis
Kieselová, Katarína; Santiago, Felicidade; Guiote, Victória; Henrique, MartinhaA 43-year-old man presented to our department with generalized erythroderma since early childhood, previously treated with topical and systemic corticosteroids with only partial improvement. The physical examination revealed polycyclic erythematous scaly plaques on the trunk and extremities and lichenification of the body folds (Fig. 1). In addition to skin lesions, we observed sparse hair of both eyebrows and ...
Retrospective Study of 109 Patients with Scabies: Profile of a Region
Kieselova, Katarina; Santiago, Felicidade; Henrique, MartinhaIntroduction: Scabies is a common cutaneous infestation occurring at any age and, in some communities, it represents a major public health problem. In Portugal, there is a lack of studies about this parasitosis. The aim of our study was to evaluate the principal characteristics of the patients with scabies diagnosed in Department of Dermatology in Centro Hospitalar de Leiria.Material and Methods: We performed a...
Oral PUVA Versus Bath PUVA in Chronic Plaque Psoriasis: A Comparative Study of ...
Kieselova, Katarina; Santiago, Felicidade; Henrique, MartinhaIntroduction: Phototherapy has long been recognized as beneficial for psoriasis treatment, with a favorable risk- -benefit relation. Photochemotherapy comprises the use of psoralen, either orally (oral PUVA) or topically (bath PUVA), prior to UVA irradiation. Oral administration of psoralen may lead to short or long-term side effects. Bath PUVA is particularly useful to minimize systemic toxicity and psoralen s...
Úlcera de Lipschütz como possível manifestação de primo-infeção por vírus Epste...
Maciel, Juliana Raquel da Costa; Kieselová, Katarina; Guiote, Victoria; Henrique, Martinha; Rezende, TeresaIntrodução: A úlcera de Lipschütz é caracterizada pelo aparecimento súbito de úlceras vulvares dolorosas em mulheres jovens sexualmente não ativas, sendo rara em crianças. A etiologia é desconhecida, mas existem estudos que a relacionam com a primo-infeção pelo vírus Epstein-Barr. O diagnóstico é equacionado após exclusão de outras causas de ulceração genital, nomeadamente autoimune, traumática e de infeções se...
Paediatric Lymphomatoid Papulosis: Diagnostic Challenges and Follow-up
Kieselová, Katarína; Santiago, Felicidade; Guiote, Victória; Henrique, Martinha; Amado, CristinaLymphomatoid papulosis is a rare primary T-cell lymphoproliferative cutaneous disorder, mostly affecting adults. Although histopathology suggests a malignant disease, in most cases, lymphomatoid papulosis is a self-limited condition with a good prognosis. We describe the case of an 8-year-old boy, otherwise healthy, who presented with a 4-6 week history of polymorphic cutaneous lesions disseminated over the who...