18 documents found, page 1 of 2
Profiling of urinary extracellular vesicle protein signatures from patients wit...
Bernardino, R; Carvalho, AS; Hall, MJ; Alves, L; Leão, R; Sayyid, R; Pereira, H; Beck, HC; Campos-Pinheiro, L; Henrique, R; Fleshner, N; Matthiesen, RPrognostic tests and treatment approaches for optimized clinical care of prostatic neoplasms are an unmet need. Prostate cancer (PCa) and derived extracellular vesicles (EVs) proteome changes occur during initiation and progression of the disease. PCa tissue proteome has been previously characterized, but screening of tissue samples constitutes an invasive procedure. Consequently, we focused this study on liqui...
Extracellular Vesicle Proteome in Prostate Cancer: A Comparative Analysis of Ma...
Bernardino, RM; Leão, R; Henrique, R; Pinheiro, LC; Kumar, P; Suravajhala, P; Beck, HC; Carvalho, AS; Matthiesen, RMolecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly explored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. ...
Emerging lab-on-a-chip approaches for liquid biopsy in lung cancer: Status in c...
Carvalho, Â; Ferreira, G; Seixas, D; Guimarães-Teixeira, C; Henrique, R; Monteiro, FJ; Jerónimo, CDespite the intensive efforts dedicated to cancer diagnosis and treatment, lung cancer (LCa) remains the leading cause of cancer-related mortality, worldwide. The poor survival rate among lung cancer patients commonly results from diagnosis at late-stage, limitations in characterizing tumor heterogeneity and the lack of non-invasive tools for detection of residual disease and early recurrence. Henceforth, resea...
Urinary extracellular vesicles as potential biomarkers for urologic cancers: An...
Lourenço, C; Constâncio, V; Henrique, R; Carvalho, Â; Jerónimo, CUrologic cancers are a heterogeneous group of tumors, some of which have poor progno-sis. This is partly due to the unavailability of specific and sensitive diagnostic techniques and monitoring tests, ideally non-or minimally invasive. Hence, liquid biopsies are promising tools that have been gaining significant attention over the last decade. Among the different classes of bi-omarkers that can be isolated from...
The Porto European Cancer Research Summit 2021
Ringborg, U; Berns, A; Celis, JE; Heitor, M; Tabernero, J; Schüz, J; Baumann, M; Henrique, R; Aapro, M; Basu, P; Beets-Tan, R; Besse, B; Cardoso, FKey stakeholders from the cancer research continuum met in May 2021 at the European Cancer Research Summit in Porto to discuss priorities and specific action points required for the successful implementation of the European Cancer Mission and Europe's Beating Cancer Plan (EBCP). Speakers presented a unified view about the need to establish high-quality, networked infrastructures to decrease cancer incidence, in...
Comparison and Optimization of DNA Extraction Methods from Cervical Cells Colle...
Silva, Andreia; Salta, S; Henrique, R; Jerónimo, CCervical cancer is the ninth leading cancer in women in Portugal. Cervical cancer screening methods have changed since the implementation of the cytology-based test developed by George Papanicolaou until the human papillomavirus-based screening. Nowadays, new biomarkers like deoxyribonucleic acid (DNA) methylation has been proposed as potential triage method of samples testing positive for human papillomavirus ...
Can epigenetic and inflammatory biomarkers identify clinically aggressive prost...
Santos, PB; Patel, H; Henrique, R; Félix, AProstate cancer (PCa) is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and mortality. It emerges through the acquisition of genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications and microRNA deregulation. These generate heritable transformations in the expression of genes but do not change the DNA sequence. Alteratio...
Disseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated...
Santos, AP; Castro, C; Antunes, L; Henrique, R; Cardoso, MH; Monteiro, MPThe association of well-differentiated gastro-entero-pancreatic neuroendocrine tumors (WD GEP-NETs) with metabolic syndrome (MetS), abdominal obesity, and fasting glucose abnormalities was recently described. The aim of this study was to evaluate whether the presence of MetS or any MetS individual component was also influenced by GEP-NET characteristics at diagnosis. A cohort of patients with WD GEP-NETs (n = 1...
Interplay between sympathetic nervous system and inflammation in aseptic loosen...
Ribeiro da Silva, M.; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJInflammation is a common symptom in joint disorders such as rheumatoid arthritis, osteoarthritis (OA) and implant aseptic loosening (AL). The sympathetic nervous system is well known to play a critical role in regulating inflammatory conditions, and imbalanced sympathetic activity has been observed in rheumatoid arthritis. In AL it is not clear whether the sympathetic nervous system is altered. In this study we...
Profiling DNA methylation based on next-generation sequencing approaches: New i...
Barros-Silva. D; Marques, CJ; Henrique, R; Jerónimo, CDNA methylation is an epigenetic modification that plays a pivotal role in regulating gene expression and, consequently, influences a wide variety of biological processes and diseases. The advances in next-generation sequencing technologies allow for genome-wide profiling of methyl marks both at a single-nucleotide and at a single-cell resolution. These profiling approaches vary in many aspects, such as DNA inp...