103 documents found, page 1 of 11
Diagnosis and Laboratory Follow-Up of Patients with Multiple Myeloma: Guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Diagnosis and laboratory follow-up of patients with multiple myeloma: guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Urinary volatile metabolomic biomarkers for detection of bladder cancer
Carapito, Ângela; Teixeira-Marques, Ana; Jerónimo, Carmen; Henrique, Rui; A. Roque, Ana Cecília; Carvalho, Félix; Pinto, Joana; Guedes de Pinho, PaulaBackground: Early detection of bladder cancer (BC) is necessary for improved outcomes, but current diagnostic methods may lack the necessary sensitivity. Metabolomics, particularly the analysis of urinary volatile organic compounds (VOCs), offers a promising, non-invasive approach to BC detection [1,2]. Objective: The study aimed to investigate potential urinary biomarkers for the detection and staging of ...
Metabolic profiling of renal cell carcinoma tissue using gas chromatography met...
Amaro, Filipa; Carvalho, Márcia; Carvalho-Maia, Carina; Jerónimo, Carmen; Henrique, Rui; Bastos, Maria de Lourdes; Guedes de Pinho, Paula; Pinto, JoanaBackground: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Metho...
Impact of high‐risk human papilloma virus genotyping in cervical disease in the...
Rosário, Andreia; Sousa, Ana Saraiva; Marinho-Dias, Joana; Medeiros, Rui; Lobo, Cláudia; Leça, Luís; Coimbra, Nuno; Tavares, Fernando; Baldaque, InêsCervical cancer prevention is based on primary prevention with vaccines againstHuman Papillomavirus (HPV) and secondary prevention by screening with High‐Risk‐HPV (Hr‐HPV) detection. Since 2017, cervical cancer screening in women aged25−60 years has been performed in Portugal using Hr‐HPV detection, followed bycytology in Hr‐HPV‐positive cases. Herein we report the prevalence of Hr‐HPVgenotypes and cytological ...
DNA methylation as a triage marker for colposcopy referral in HPV-based cervica...
Salta, Sofia; Lobo, João; Magalhães, Bruno; Henrique, Rui; Jerónimo, CarmenScreening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontline for screening programs. Thus, the importance of effective triage strategies, including DNA methylation markers, has been emphasized. Despite the potential reported in individual studies, methylation mar...
A peptide-centric approach to analyse quantitative proteomics data- an applicat...
Lima, Tania; Rodrigues, João Eduardo; Manadas, Bruno; Henrique, Rui; Fardilha, Margarida; Vitorino, RuiBottom-up proteomics is a popular approach in molecular biomarker research. However, protein analysts have realized the limitations of protein-based approaches for identifying and quantifying proteins in complex samples, such as the identification of peptides sequences shared by multiple proteins and the difficulty in identifying modified peptides. Thus, there are many exciting opportunities to improve analysis...
Galectin-3 in prostate cancer and heart diseases: a biomarker for these two fri...
Lima, Tânia; Perpétuo, Luís; Henrique, Rui; Fardilha, Margarida; Leite-Moreira, Adelino; Bastos, Jose; Vitorino, RuiGalectin-3 (Gal-3) belongs to galectin protein family, a type of β-galactose-binding lectin having more than one evolutionarily conserved domain of carbohydrate recognition. Gal-3 is mainly located in the cytoplasm, but it also enters the nucleus and is secreted into the extracellular environment and biological fluids such as urine, saliva, and serum. It plays an important role in many biological functions, suc...
Gal-3 Protein Expression and Localization in Prostate Tumours
Lima, Tânia; Macedo-Silva, Catarina; Felizardo, Diana; Fraga, João; Carneiro, Isa; Jerónimo, Carmen; Henrique, Rui; Fardilha, Margarida; Vitorino, RuiGal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-rela...
The modulatory role of internet-supported mindfulness-based cognitive therapy o...
Pereira, Diana R.; Silva, Eunice R.; Carvalho-Maia, Carina; Monteiro-Reis, Sara; Lourenço, Catarina; Calisto, Rita; Teixeira, Ricardo JoãoMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which...