10 documents found, page 1 of 1
Unraveling the genetic basis of subclinical atherosclerosis
Sá, Débora; Mendonça, Maria Isabel; Serrão, Marco; Sousa, Francisco; Abreu, Gonçalo; Henriques, Eva; Borges, Sofia; Freitas, Sónia; Rodrigues, MarianaPublisher Copyright: © 2025 Sociedade Portuguesa de Cardiologia; Introduction and objectives: Decoding the genetic basis of coronary artery disease (CAD) through an intermediate phenotype – coronary calcification – can help us to better understand this deadly disease and enable the creation of better therapeutic strategies. This work aims to assess the relationship between a set of single nucleotide polymorphis...
Association of Obesity-Related Genetic Variants with Android Fat Patterning and...
Sá, Débora; Mendonça, Maria Isabel; Sousa, Francisco; Abreu, Gonçalo; Ferreira, Matilde; Henriques, Eva; Freitas, Sónia; Rodrigues, MarianaBackground/Objectives: The location and distribution of excess fat, rather than overall adiposity, are stronger predictors of cardiometabolic risk and are commonly assessed using the waist-to-hip ratio (WHR). Fat distribution in women has a heritable component, yet the genetic factors that influence it remain poorly understood. We aim to assess the association between obesity-related polymorphisms with WHR and ...
Validation of the SCORE2 risk prediction algorithm in a Portuguese population
Temtem, Margarida; Mendonça, Maria Isabel; Santos, Marina; Sá, Débora; Sousa, Francisco; Freitas, Sónia; Borges, Sofia; Henriques, EvaPublisher Copyright: © 2024 Sociedade Portuguesa de Cardiologia; Introduction and Objectives: Subjects without cardiovascular (CV) disease (CVD) may suffer from subclinical atherosclerosis, and are at increased risk for atherosclerotic CV events (ASCVE). The ESC/EAS risk SCORE was updated by SCORE2, which estimates 10-year risk of fatal and non-fatal CVD in European populations aged 40–69 years without establis...
Impact of genetic information on coronary disease risk in Madeira
Mendonça, Maria Isabel; Pereira, Andreia; Monteiro, Joel; Sousa, João Adriano; Santos, Marina; Temtem, Margarida; Borges, Sofia; Henriques, EvaCopyright © 2022 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.; INTRODUCTION: Coronary artery disease (CAD), characterized by an atherogenic process in the coronary arteries, is one of the leading causes of death in Madeira. The GENEMACOR (GENEs in MAdeira and CORonary Disease) study sought to investigate the main risk factors - environmental and genetic - and e...
WITHDRAWN
Mendonça, Maria Isabel; Pereira, Andreia; Monteiro, Joel; Sousa, João Adriano; Santos, Marina; Temtem, Margarida; Borges, Sofia; Henriques, EvaCopyright © 2022. Publicado por Elsevier España, S.L.U.; The Publisher regrets that this article is an accidental duplication of an article that has already been published, 10.1016/j.repc.2022.10.005. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Epicardial Adipose Tissue
Sousa, João Adriano; Mendonça, Maria Isabel; Serrão, Marco; Borges, Sofia; Henriques, Eva; Freitas, Sónia; Tentem, Margarida; Santos, MarinaPublisher Copyright: © The Author(s) 2021.; Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 p...
Additional value of a combined genetic risk score to standard cardiovascular st...
Pereira, Andreia Micaela; Mendonca, Maria Isabel; Borges, Sofia; Sousa, Ana Célia; Freitas, Sónia; Henriques, Eva; Rodrigues, MarianaThe utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic varia...
Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa...
Sousa, Ana Célia; Reis, Roberto Palma; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara; Góis, Teresa; Nóbrega, LinoINTRODUCTION: Arterial hypertension is a complex, multifactorial disease, controlled by genetic and environmental factors. OBJECTIVE: Evaluate the genetic susceptibility for developing arterial hypertension and its association with the traditional risk factors in the outbreak of this pathology. MATERIAL AND METHODS: Case-control study with 1712 individuals, mean age of 51.0 ± 7.9 years (860 hypertensive patient...
Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in...
Pereira, Andreia; Mendonça, Maria Isabel; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana Isabel; Sousa, Ana CéliaBACKGROUND: Genetic risk score can quantify individual's predisposition to coronary artery disease; however, its usefulness as an independent risk predictor remains inconclusive. OBJECTIVE: To evaluate the incremental predictive value of a genetic risk score to traditional risk factors associated with coronary disease. METHODS: Thirty-three genetic variants previously associated with coronary disease were analy...
A variante genética c825t da subunidade β3 da proteína G associa‐se com a hiper...
Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana Isabel; Guerra, GraçaFinanciamento: Programa Operacional de Valorização do Potencial Económico e Coesão Territorial da Região Autónoma da Madeira (Intervir+); Introduction: Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads...