36 documents found, page 1 of 4
O processamento sensorial e a sua relação com o desempenho escolar
Henriques, Andreia; Silva, Cláudia Ribeiro da; Reis, HelenaO estudo pretende verificar se existe relação entre o processamento sensorial e o desempenho escolar. Constituiu-se uma amostra de 47 sujeitos que frequentavam o 2.º ano do 1.º Ciclo do Ensino Básico. Aplicou-se a Sensory Processing Measure (SPM) - Forma Casa e Forma Sala de Aula e a Bateria de Aptidões para a Aprendizagem Escolar (BAPAE), relacionando-as com as avaliações escolares. Observaram-se mais problema...
O processamento sensorial e o desempenho escolar
Henriques, AndreiaO estudo pretende verificar se existe relação entre o processamento sensorial e o desempenho escolar. Constituiu-se uma amostra de 47 sujeitos que frequentavam o 2.º ano do 1.º Ciclo do Ensino Básico. Aplicou-se a Sensory Processing Measure (SPM) - Forma Casa e Forma Sala de Aula e a Bateria de Aptidões para a Aprendizagem Escolar (BAPAE), relacionando-as com as notas escolares. Observaram-se mais problemas no ...
Is the proteome of bronchoalveolar lavage extracellular vesicles a marker of ad...
Carvalho, Ana Sofia; Moraes, Maria Carolina Strano; Hyun Na, Chan; Fierro-Monti, Ivo; Henriques, Andreia; Zahedi, Sara; Bodo, CristianAcellular bronchoalveolar lavage (BAL) proteomics can partially separate lung cancer from non-lung cancer patients based on principal component analysis and multivariate analysis. Furthermore, the variance in the proteomics data sets is correlated mainly with lung cancer status and, to a lesser extent, smoking status and gender. Despite these advances BAL small and large extracellular vehicles (EVs) proteomes r...
Protein kinase WNK1 contributes to the regulation of GLUT1 expression in the pl...
Henriques, Andreia; Matthiesen, Rune; Matos, Paulo; Jordan, PeterIntroduction: One mechanism by which tumour cells regulate the uptake of glucose is overexpression of glucose transporter proteins (GLUT). Besides their expression level, the number of GLUT present at the plasma membrane is regulated by signaling mechanisms (1). Previously we found that protein kinase WNK1 phosphorylates TBC1D4 (2), a GTPase activating protein for RAB-family proteins involved in membrane traffi...
Regulation of the Alternative Splicing of Tumor-Related RAC1B by Signal Transdc...
Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Henriques, Andreia; Jordan, PeterIntroduction: In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1B, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we...
Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Relat...
Gonçalves, Vânia; Matos, Paulo Matos; Pereira, Joana; Henriques, Andreia; Jordan, PeterIntroduction: In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we...
Protein kinase-mediated regulation of glucose transporters translocation to the...
Henriques, Andreia; Matos, Paulo; Jordan, PeterCancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so...
New insights into how cancer cells regulate glucose uptake by protein phosphory...
Henriques, Andreia; Matos, Paulo; Jordan, PeterIntroduction: Cancer cells require increased amounts of glucose to sustain their proliferation and upregulate plasma membrane expression of glucose transporter GLUT1. In insulin responsive cells, glucose uptake requires previous phosphorylation of TBC1D4, a negative regulator of endosomal GLUT traffic. Previous work published by the host lab has discovered that protein kinase WNK1 can also phosphorylate TBC1D4 ...
Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transdu...
Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Henriques, Andreia; Jordan, PeterDistinct genetic subtypes have been described in colon cancer, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogeneinduced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how si...
Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transdu...
Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Henriques, Andreia; Jordan, PeterIntroduction; In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we...