36 documents found, page 1 of 4
Association of Obesity-Related Genetic Variants with Android Fat Patterning and...
Sá, Débora; Mendonça, Maria Isabel; Sá, Débora; Sousa, Francisco; Abreu, Gonçalo; Ferreira, Matilde; Henriques, Eva; Freitas, Sónia; Rodrigues, MarianaBackground/Objectives: The location and distribution of excess fat, rather than overall adiposity, are stronger predictors of cardiometabolic risk and are commonly assessed using the waist-to-hip ratio (WHR). Fat distribution in women has a heritable component, yet the genetic factors that influence it remain poorly understood. We aim to assess the association between obesity-related polymorphisms with WHR and ...
Unraveling the genetic basis of subclinical atherosclerosis
Sá, Débora; Mendonça, Maria Isabel; Serrão, Marco; Sousa, Francisco; Abreu, Gonçalo; Henriques, Eva; Borges, Sofia; Freitas, Sónia; Rodrigues, MarianaIntroduction and objectives: Decoding the genetic basis of coronary artery disease (CAD) through an intermediate phenotype – coronary calcification – can help us to better understand this deadly disease and enable the creation of better therapeutic strategies. This work aims to assess the relationship between a set of single nucleotide polymorphisms (SNPs) previously associated with CAD and coronary artery calc...
Validation of the SCORE2 risk prediction algorithm in a Portuguese population
Temtem, Margarida; Mendonça, Maria Isabel; Santos, Marina; Sá, Débora; Sousa, Francisco; Freitas, Sónia; Borges, Sofia; Henriques, EvaIntroduction and Objectives: Subjects without cardiovascular (CV) disease (CVD) may suffer from subclinical atherosclerosis, and are at increased risk for atherosclerotic CV events (ASCVE). The ESC/EAS risk SCORE was updated by SCORE2, which estimates 10-year risk of fatal and non-fatal CVD in European populations aged 40–69 years without established CVD or diabetes. Our aim was to compare the two ESC/EAS risk ...
Impact of genetic information on coronary disease risk in Madeira
Mendonça, Maria Isabel; Pereira, Andreia; Monteiro, Joel; Sousa, João Adriano; Santos, Marina; Temtem, Margarida; Borges, Sofia; Henriques, EvaINTRODUCTION: Coronary artery disease (CAD), characterized by an atherogenic process in the coronary arteries, is one of the leading causes of death in Madeira. The GENEMACOR (GENEs in MAdeira and CORonary Disease) study sought to investigate the main risk factors - environmental and genetic - and estimate whether a genetic risk score (GRS) improves CAD prediction, discrimination and reclassification. METHODS: ...
Epicardial adipose tissue is a promising imaging biomarker of subclinical ather...
Mendonça, Maria Isabel; Sousa, João Adriano; Serrão, Marco; Santos, Marina; Temtem, Margarida; Sá, Débora; Sousa, Francisco; Henriques, EvaIdentifying markers to discriminate high and low-risk individuals better is essential. Coronary Calcium Score (CAC) is an established marker of subclinical atherosclerosis. Epicardial Adipose Tissue (EAT), a new imaging biomarker, has shown considerable interest in the scientific community.
WITHDRAWN
Mendonça, Maria Isabel; Pereira, Andreia; Monteiro, Joel; Sousa, João Adriano; Santos, Marina; Temtem, Margarida; Borges, Sofia; Henriques, EvaThe Publisher regrets that this article is an accidental duplication of an article that has already been published, 10.1016/j.repc.2022.10.005. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Genetic information improves the prediction of major adverse cardiovascular eve...
Mendonca, Maria Isabel; Henriques, Eva; Borges, Sofia; Sousa, Ana Célia; Pereira, Andreia; Santos, Marina; Temtem, Margarida; Freitas, SóniaThe inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from the GENE...
Alteração da Alimentação e atividade física em social: experiência da Região Au...
Costa, Liliane; Henriques, Eva; Esmeraldo, TeresaINTRODUÇÃO: As medidas de contenção social impostas durante a pandemia COVID-19 resultaram em restrições na vida diária e, consequentemente em alterações ao estilo de vida. Conhecer o efeito destas medidas nos hábitos alimentares e atividade física será importante para definir respostas de Saúde Pública ajustadas e em tempo útil. OBJETIVOS: Avaliar o efeito do período de contenção social na perceção da alteraçã...
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk ...
Sousa, João Adriano; Mendonca, Maria Isabel; Serrão, Marco; Borges, Sofia; Henriques, Eva; Freitas, Sónia; Tentem, Margarida; Santos, MarinaEvidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a...
Epicardial Adipose Tissue
Sousa, João Adriano; Mendonça, Maria Isabel; Serrão, Marco; Borges, Sofia; Henriques, Eva; Freitas, Sónia; Tentem, Margarida; Santos, MarinaEvidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a...