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Side effects of electrochemotherapy in cats with squamous cell carcinoma: a ret...

Zeferino, Ana Rita; Henriques, J; Faustino-Rocha, Ana Isabel; Serras, Ana Rita

Eletrochemotherapy (EQT) is an emerging therapeutic modality in Veterinary Oncology that combines the intravenous (IV) or intratumoral (IT) administration of chemotherapeutic agents with the application of electrical pulses(1). This therapy has been described to induce significant cancer remission in cutaneous squamous cell carcinoma (SCC) and a reduction of chemotherapeutic dosages, maximizing intracellular co...


HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...

Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, D

Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...


Global Chronic Total Occlusion Crossing Algorithm

Wu, EB; Brilakis, ES; Mashayekhi, K; Tsuchikane, E; Alaswad, K; Araya, M; Avran, A; Azzalini, L; Babunashvili, AM; Bayani, B; Behnes, M; Bhindi, R

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using th...

Date: 2021   |   Origin: Lusíadas Saúde


Guidelines for the Management of Center-Involving Diabetic Macular Edema: Treat...

Figueira, J; Henriques, J; Carneiro, A; Marques-Neves, C; Flores, R; Castro-Sousa, JP; Meireles, A; Gomes, N; Nascimento, J; Amaro, M; Silva, R

Diabetic macular edema (DME) is the main cause of visual impairment associated with diabetic retinopathy (DR) and macular laser, during approximately three decades, and was the single treatment option. More recently, intravitreous injections of anti-angiogenics and corticosteroids modified the treatment paradigm associated with significant vision improvements. Nevertheless, not all patients respond satisfactori...


The role of bacteria in pine wilt disease: insights from microbiome analysis.

Alves, Marta; Henriques, Isabel; Pereira, A; Vicente, Cláudia; Mota, Manuel; Matos, P; Henriques, J; Lopes, H; Nascimento, F; Correia, A

Pine Wilt Disease (PWD) has a significant impact on Eurasia pine forests. The microbiome of the nematode (the primary cause of the disease), its insect vector, and the host tree may be relevant for the disease mechanism. The aim of this study was to characterize these microbiomes, from three PWD-affected areas in Portugal, using Denaturing Gradient Gel Electrophoresis, 16S rRNA gene pyrosequencing, and a functi...


A Nonrandomized, Open-Label, Multicenter, Phase 4 Pilot Study on the Effect and...

Figueira, J; Henriques, J; Amaro, M; Rosas, V; Alves, D; Cunha-Vaz, J

PURPOSE: The aim of this study was to assess the effectiveness and safety of ILUVIEN® in patients with chronic diabetic macular edema (DME) who were insufficiently responsive to prior therapies. METHODS: This is a prospective, nonrandomized, multicenter, open-label, phase 4 pilot study assessing the effectiveness and safety of ILUVIEN® involving 12 patients insufficiently responsive to available therapies. Asse...


Bacterial community associated to the pine wilt disease insect vectors Monocham...

Alves, M; Pereira, A; Matos, P; Henriques, J; Vicente, Cláudia; Aikawa, T; Hasegawa, K; Nascimento, Francisco; Mota, Manuel; Correia, A; Henriques, I

Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect survival. The aim of this study was to characterize the bacterial community associated to PWD vectors in Europe and East Asia using a culture-independent appro...


A Nonrandomized, Open-Label, Multicenter, Phase 4 Pilot Study on the Effect and...

Figueira, J; Henriques, J; Amaro, M; Rosas, V; Alves, D; Cunha-Vaz, J

PURPOSE: The aim of this study was to assess the effectiveness and safety of ILUVIEN® in patients with chronic diabetic macular edema (DME) who were insufficiently responsive to prior therapies. METHODS: This is a prospective, nonrandomized, multicenter, open-label, phase 4 pilot study assessing the effectiveness and safety of ILUVIEN® involving 12 patients insufficiently responsive to available therapies. Asse...


Three-Dimensional Head-Mounted Display System for Ophthalmic Surgical Procedures

Dutra Medeiros, M; Nascimento, J; Henriques, J; Barrão, S; Fernandes-Fonseca, A; Aguiar-Silva, N; Moura-Coelho, N; Ágoas, V


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