3 documents found, page 1 of 1
Biflorin : an o-naphthoquinone of clinical significance
Wisintainer, Gabrielle G. N. S.; Simões, Evelyne R. B.; Lemos, Telma L. G.; Moura, Sidnei; Souza, Luciana G. S.; Fonseca, Aluisio M.Biflorin is an o -naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against gram- positiv...
Inhibition of DNA topoisomerase I activity and induction of apoptosis by thiaza...
Barros, Francisco W.A.; Bezerra, Daniel P.; Ferreira, Paulo M. P.; Cavalcanti, Bruno C.; Silva, Teresinha G.; Pitta, Marina G. R.Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione — AC-4; (5ZE)-5-acridin-9- ylmethylene-3-(4-bromo-benzyl)-thiazolidine-2,4-dione — AC-7; (5Z)-5-(acridin-9-ylmethylene)-3-...
Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...