5 documents found, page 1 of 1
Novel Oxygen- and Curcumin-Laden Ionic Liquid@Silica Nanocapsules for Enhanced ...
Henriques, Joana F.; Pina, João; Braga, Mara E. M.; Dias, Ana M. A.; Coimbra, Patrícia; Sousa, Herminio C. deThe efficiency of photodynamic therapy is often limited by the scarcity of oxygen at the target site. To address this problem, this work proposes the development of a new nanosystem for antimicrobial photodynamic therapy applications (aPDT) where the natural-origin photosensitizer curcumin (CUR) is immersed in an oxygen-rich environment. Inspired by the perfluorocarbon-based photosensitizer/O2 nanocarriers repo...
The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the P...
Henriques, Joana F.; Serra, Diana; Dinis, Teresa C. P.; Almeida, Leonor M.Anthocyanins are naturally occurring polyphenols commonly found in fruits and vegetables. Numerous studies have described that anthocyanin-rich foods may play a crucial role in the prevention and treatment of different pathological conditions, which have encouraged their consumption around the world. Anthocyanins exhibit a significant neuroprotective role, mainly due to their well-recognized antioxidant and ant...
An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its ...
Serra, Diana; Henriques, Joana F.; Serra, Teresa; Silva, Andreia Bento; Bronze, Maria Rosário; Dinis, Teresa C. P.; Almeida, Leonor M.Dietary polyphenols are multi-target compounds that have been considered promising candidates in strategies for the mitigation of neurological diseases, acting particularly through reduction of microglia-driven neuroinflammation. In this study, an anthocyanin-rich extract obtained from Portuguese blueberries was subjected to a simulated gastrointestinal digestion; after chemical characterisation, the potential ...
Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology a...
Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; Magalhães, JoãoNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory ...
Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology a...
Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; Magalhães, JoãoNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory ...