19 documents found, page 1 of 2

Foveal avascular zone area measurement in diabetic patients: superficial, deep ...

Purpose: To compare differences in the foveal avascular zone (FAZ) area, measured in the Superficial Vascular Complex (SVC), Deep Vascular Complex (DVC), and a combined analysis of both (SDVC), using two Spectral Domain OCT angiography (OCT-A) protocols, High Speed (HS) and High Resolution (HR). Methods: A total of 26 eyes of diabetic patients, with and without macular oedema, were examined with two different f...

DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...

Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...

Retinopatia Diabética - Orientações Clínicas 2023

Documento: RD-gdl 0010 GER Portugal versão 1.2 Out-2023 (Este Documento esteve em discussão no GER e na SPO até 31 de Outubro de 2023 para recolha de opinião de todos os interessados de forma a melhorar o seu conteúdo e obter o maior consenso possível. A todos os colegas que deram o seu contributo, o grupo de trabalho agradece a colaboração.)

DNA methyltransferase expression (DNMT1, DNMT3a and DNMT3b) as a potential biom...

Purpose: DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of DNA methyltransferase with diabetic macular edema is still unknown. We aimed to describe the differences in DNA methyltransferase gene expression in patients with different diabetic macular edema responses. Methods: A total of 27 diabetic patients, aged 59-90 years, were pro...

Structural Fire Performance of Concrete-Filled Built-Up Cold-Formed Steel Columns

Concrete-filled composite columns are widely used in the construction industry, exploiting the benefits of combining steel and concrete, providing, for instance, high load-bearing capacities and enhanced fire resistance. These solutions are extensively used in high-rise buildings and/or when high fire resistance performance requirements are imposed. In this exploratory research, a new type of concrete-filled co...

Role of DNA methylation in persistent diabetic macular edema

Background: a) Disease duration and metabolic control are insufficient to understand Diabetic Macular Edema (DME), the leading cause of vision loss in people with diabetes; b) 30-40% of cases of DME do not respond optimally to AVEGF (loading phase); c) poor genetic association in DR development (<25% RD) and PDR progression (25-50%). Purpose: To study the role of DNA methyltransferase expression (DNMT1,DNMT3a, ...

Challenges, facilitators and barriers to the adoption and use of a web-based na...

Rare disease registries increase research accessibility for patients, while providing clinicians/investigators with a coherent data ecosystem necessary to boost research and patient care. The IRD-PT registry is a national, web-based, interoperable registry for inherited retinal degenerations (IRDs) designed to generate scientific knowledge and collect high-quality data on the epidemiology, genomic landscape and...

Guidelines for the Management of Center-Involving Diabetic Macular Edema: Treat...

Diabetic macular edema (DME) is the main cause of visual impairment associated with diabetic retinopathy (DR) and macular laser, during approximately three decades, and was the single treatment option. More recently, intravitreous injections of anti-angiogenics and corticosteroids modified the treatment paradigm associated with significant vision improvements. Nevertheless, not all patients respond satisfactori...

Diclofenac release from a silicon based contact lens material controlled by a c...

Contact lenses as drug controlled release systems: a narrative review

Topically applied therapy is the most common way to treat ocular diseases, however given the anatomical and physiological constraints of the eye, frequent dosing is required with possible repercussions in terms of patient compliance. Beyond refractive error correction, contact lenses (CLs) have, in the last few decades emerged as a potential ophthalmic drug controlled release system (DCRS). Extensive research i...