8 documents found, page 1 of 1
Smoking Induces a Decline in Semen Quality and the Activation of Stress Respons...
Henriques, Magda Carvalho; Santiago, Joana; Patrício, António; Herdeiro, Maria Teresa; Loureiro, Susana; Fardilha, MargaridaMale infertility is a prevalent concern affecting couples worldwide. While genetic factors, hormonal imbalances, and reproductive system defects play significant roles, emerging evidence suggests that lifestyle choices also profoundly impact male fertility. This study aimed to explore the effects of several lifestyle factors, including tobacco and alcohol consumption, physical activity, and dietary habits, on s...
The World Café method and spaces dedicated to active teaching & learning: A dyn...
Pinto-Pinho, Patrícia; Ferreira, Ana; Matos, Bárbara; Santiago, Joana; Henriques, Magda Carvalho; Corda, Pedro Oliveira; Lima, Tânia; Rodrigues, MárioA pilot experiment was developed in a Biomedical Sciences curricular unit to test how using a different knowledge-sharing method (World Café) in a Space for Active Learning and Teaching would affect students’ engagement. Each working group was asked to prepare a poster summarising a different topic about the physiology of the oocyte. On the activity day, rotating discussion sessions moderated by tutors took pla...
Unveiling the molecular mechanisms and developmental consequences of mercury (H...
Henriques, Magda Carvalho; Carvalho, Inês; Santos, Cátia; Herdeiro, Maria Teresa; Fardilha, Margarida; Pavlaki, Maria Dimitriou; Loureiro, SusanaMercury (Hg) is a global contaminant affecting aquatic ecosystems' health. Chronic exposure to Hg has shown that the normal development of zebrafish embryo-larvae is affected. However, the molecular mechanisms behind the toxicity of Hg on fish embryonic development are still poorly understood. This work aimed to investigate the effects of Hg exposure on zebrafish embryo-larvae using a combined approach at indiv...
The role of endocrine-disrupting chemicals in male fertility decline
Henriques, Magda Carvalho; Loureiro, Susana; Fardilha, Margarida; Herdeiro, Maria TeresaEndocrine-disrupting chemicals (EDCs) are exogenous compounds with natural or anthropogenic origin omnipresent in the environment. These compounds disrupt endocrine function through interaction with hormone receptor or alteration of hormone synthesis. Humans are environmentally exposed to EDCs through the air, water, food and occupation. During the last decades, there has been a concern that exposure to EDCs ma...
Exposure to mercury and human reproductive health: a systematic review
Henriques, Magda Carvalho; Loureiro, Susana; Fardilha, Margarida; Herdeiro, Maria TeresaBackground Evidences from human and animal studies suggest that reproductive function may be affected by mercury. The aim of this review was to explore the mercury influence on human fertility. Methods A systematic search was made in PubMED for papers published between 1975–2017, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Increased mercury levels were...
Understanding prostate cancer cells metabolome: a spectroscopic approach
Santos, Francisco; Magalhães, Sandra; Henriques, Magda Carvalho; Silva, Beatriz; Valença, Isabel; Ribeiro, Daniela; Fardilha, MargaridaIntroduction: Prostate Cancer (PCa) is the second most common neoplasia in men. Because it is often diagnosed at a late stage, mortality rates remain high. Studying cancer metabolome, which reflects early changes that occur in cells, has gained relevance and may contribute to the identification of early diagnostic biomarkers and understanding tumor biology. Methods: Fourier-transform infrared (FTIR) spectroscop...
Spectroscopic features of cancer cells: FTIR spectroscopy as a tool for early d...
Santos, Francisco; Magalhães, Sandra; Henriques, Magda Carvalho; Fardilha, Margarida; Nunes, AlexandraGlobally, cancer is one of the leading causes of death, so the development of strategies for an early diagnosis of cancer is of great importance. Biochemical alterations precede morphological changes in cells and tissues, so studying cancer metabolome seems like a reasonable approach for early diagnosis, prognosis and to follow treatment progression. Fourier-transform infrared (FTIR) spectroscopy is a valuable ...
A ruthenium(II)-trithiacyclononane curcuminate complex: synthesis, characteriza...
Henriques, Magda Carvalho; Faustino, Maria Amparo F.; Silva, Artur M. S.; Felgueiras, Juliana; Fardilha, Margarida; Braga, Susana SantosThe coordination of ruthenium(II) complexes to anionic oxygen-based donors are very rare. This study describes a simple, one-pot method for obtaining [ruthenium(II)(trithiacyclononane)(curcumin)(S-DMSO)]Cl (1) in 37% yield. The structural characterization of complex 1 by elemental analysis, FT-IR, 1-D and 2-D NMR, ESI+-MS as well as UV–vis and fluorescence spectroscopies are presented. The DNA-melting temperatu...