465 documents found, page 1 of 47
CUsKit: a test to revolutionise the evaluation of the disinfection process
Castro, Débora; Ferreri, Isabel; Henriques, Mariana; Carvalho, IsabelThe overuse of surface disinfectants has been shown to lead to increased microbial resistance, often due to their incorrect application. The aim of this work was to develop and investigate the use of an indicative detection kit for hydrogen peroxide-based disinfectants on porous and non-porous surfaces. The detection kit allows for the detection of the disinfectant up to 7 days after its application, resulting ...
Towards a machine learning framework for predicting MicroRNAs involved in Candi...
Miranda, Tiago; Ferraz, Filipa; Henriques, Mariana; Silva, Sónia Carina; Gonçalves, Bruna FernandesInfections caused by Candida species present significant clinical challenges, leading to high morbidity and mortality rates. Emerging research suggests that microRNAs (miRNAs) may serve as valuable biomarkers for diagnosing and treating candidiasis, although the field is still developing. The scarcity of reported miRNAs associated with candidiasis stems from the complexities and costs of screening numerous pote...
Application of antisense therapy to control Nakaseomyces glabratus infections
Serra, Patrícia; Gonçalves, Bruna; Henriques, Mariana; Castro, Joana; Araújo, Daniela; Silva, Sónia CarinaCanclicla infections affect billions of people worlclwicle, with high morbidity ancl mortality rates (40-60CX,) [l] ancl require long hospital stays ancl increase healthcare costs, which places a significant socio-economic burclen on the economy [2]. Canclicla glabrata (now reclassified as Nakaseomyces glabratus) poses a significant clinical challenge, clue to its increasing levels of resistance to conventional...
Comprehensive molecular characterization of anti-EFG1 2'OMe effects on C. albic...
Silva, Diana; Silva, Sónia Carina; Henriques, Mariana; Araújo, Daniela; Gonçalves, Bruna FernandesCandidiasis is a fungal infection primarily caused by Candida albicans. It affects millions of people worldwide and poses significant clinical challenges, resulting in high morbidity and mortality rates, largely due to increasing resistance to conventional antifungal therapies resulting from their widespread use [1]. Innovative therapies, such as antisense oligonucleotides (ASOs), are being explored to address ...
Durable and breathable ZnO/graphene-coated fabrics for enhanced BQR protection
Ferreira, Tânia; Vale, A. Catarina; Gonçalves, Afonso; Pinto, Alexandra C.; Sousa, Diana; Guimarães, Humberto; Moreira, Inês P.; Silva, CarlosThis work developed a new strategy to create active protection against chemical, biological, radiological and nuclear (CBRN) threats, based on polyurethane-based coatings for outer (water and oil-repellency) and inner (CBRN protection) functionalization of fabric. The internal coatings were functionalized with varying concentrations of zinc oxide nanoparticles (ZnO) and/or graphene nanoplatelets (Gf) and carefu...
Vapor phase of white thyme essential oil: effect on Candida albicans and preser...
Fernandes, Liliana Sousa; Silva, Inês da; Araújo, Daniela Eira; Costa, Raquel Pinho; Silva, Sónia Carina; Mira, Nuno Pereira; Costa-de-Oliveira, SofiaThe balance of the vaginal ecosystem results from synergistic interactions established between the different colonizing microorganisms. Lactobacillus spp. stands out as a predominant member, acting a crucial protective role in maintaining vaginal health. As vulvovaginal candidiasis remains prevalent and antifungal resistance grows, there is a pressing need for alternative therapies. However, any development of ...
Chemical composition, biocompatibility, and anti-Candida albicans activity of S...
Andrade, João; Almeida-Apolonio, Adriana; Dantas, Fabiana; Nogueira, Cláudio; Pinto, Luciano; Moraes, Carlos; Fernandes, Liliana SousaRecurrent vulvovaginal candidiasis (RVVC), predominantly caused by Candida albicans, represents a global health issue, particularly in developing regions. This study explores the antifungal potential of aqueous leaf extract of Schinus weinmanniifolia Mart. ex Engl., a native Latin American plant. The extract was evaluated for phytochemical composition, antifungal efficacy, and safety profile. Phytochemical anal...
Glycyrrhiza glabra hydroethanolic extract and manuka honey alone and in combina...
Gomes, Fernanda; Dias, Maria Inês; Rodrigues, Maria Elisa; Barros, Lillian; Henriques, MarianaThe natural tendency of polymicrobial infections and co-habitation of bacteria and Candida are currently well-recognized and reported as highly fatal. This kind of interaction is usually associated with drug tolerance, infection relapse, persistence and high mortality. The interest in natural products has emerged and their potential applicability as therapeutic strategies is being constantly explored. Purpose: ...
Validation of the Portuguese version of the Integration of Stressful Life Exper...
Albuquerque, Sara; Henriques, Mariana; Rosa, Pedro Joel; Delalibera, Mayra; Neimeyer, Robert A.; Coelho, Alexandra; Batista, JoãoThe Integration of Stressful Life Experiences Scale (ISLES) evaluates the ability to integrate stressful experiences into one's meaning system. This study aimed to validate ISLES for the Portuguese population, utilizing a sample of 242 adults who had lost a significant other. The sample was predominantly female, educated, married, or in consensual unions, and actively employed. Confirmatory factor analysis reve...
Development and evaluation of microencapsulated oregano essential oil as an alt...
Fernandes, Liliana Sousa; Barco-Tejada, Ainara; Blázquez, Elena; Araújo, Daniela Eira; Ribeiro, Artur; Silva, Sónia Carina; Cussó, LorenaVulvovaginal candidiasis (VVC) is characterized as a very common fungal infection that significantly affects womens health worldwide. Essential oils (EOs) are currently being evaluated as an alternative therapy. The development of efficient techniques such as micro- or nanoencapsulation for protecting and controlling release is essential to overcome the limitations of EO applications. Therefore, the aim of this...