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An endoribonuclease of the YicC-like family delays sporulation via sRNA degrada...
Martins, Diogo; Salgueiro, Bruno; Sobral, Daniel; Gragera, Marcos; Hensel, Zach; Henriques, Adriano O.; Romão, Célia V.; Serrano, MónicaFunding Information: This project was supported by award PTDC/BIA-MIC/29293/2017 to M.S. and has received funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No. 857203 to C.V.R. This study was financially supported by the Portuguese Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Projects MOSTMICRO-ITQB with references UIDB/04612/2020, and LS4FUT...
A Critical Reexamination of Recovered SARS-CoV-2 Sequencing Data
Débarre, Florence; Hensel, ZachFunding Information: Z.H. was supported by FCT - Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit ( https://doi.org/10.54499/UIDB/04612/2020 ; https://doi.org/10.54499/UIDP/04612/2020 ) and LS4FUTURE Associated Laboratory ( https://doi.org/10.54499/LA/P/0087/2020 ). Publisher Copyright: © 2025 The Author(s). Published by Oxford University Press on behalf of Society fo...
Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 s...
Santos, Cristiana C.; Schweizer, Nadine; Cairrão, Fátima; Ramirez, Juanma; Osinalde, Nerea; Yang, Ming; Gaspar, Catarina J.; Rasheva, Vanya I.Funding Information: We would like to thank Hyung Don Ryoo, Andreas Bergmann, Iswar Hariharan, Patrick Emery, the Bloomington Drosophila Stock Center, FlyORF and the Developmental Studies Hybridoma Bank (DSHB) for fly stocks, plasmids and antibodies. We would like to thank Hyung Don Ryoo, Avi Ashkenazi and Brenda Schulman for comments on the manuscript. We thank Julia Domingos (Insta: cenasdajul) for the art wo...
Cell constriction requires processive septal peptidoglycan synthase movement in...
Schäper, Simon; Brito, António D.; Saraiva, Bruno M.; Squyres, Georgia R.; Holmes, Matthew J.; Garner, Ethan C.; Hensel, Zach; Henriques, RicardoFunding Information: We thank members of the Pinho lab, P. Pereira (ITQB-NOVA), S. Filipe (FCT-NOVA) and J. Xiao (Johns Hopkins University) for helpful discussions; L. Lavis (Janelia Research Campus, Ashburn) for the generous gift of JF549-HTL, JF549-cpSTL and JFX650-STL; E. Harry (University of Technology, Sydney) for providing the anti-FtsZ antibody; T. Roemer (Merck) for providing DMPI; M. S. VanNieuwenhze (...
Conformational changes in the essential E. coli septal cell wall synthesis comp...
Britton, Brooke M.; Yovanno, Remy A.; Costa, Sara F.; McCausland, Joshua; Lau, Albert Y.; Xiao, Jie; Hensel, ZachFunding Information: The authors thank all members of the Hensel, Xiao, and Lau laboratories for helpful discussions and feedback on the manuscript. Z.H. received support for this work from FCT—Fundação para a Ciência e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020, UIDP/04612/2020, Z.H.) and LS4FUTURE Associated Laboratory (LA/P/0087/2020, Z.H.), from a joint research agreement with the ...
SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replicatio...
Zimmermann, Liv; Zhao, Xiaohan; Makroczyova, Jana; Wachsmuth-Melm, Moritz; Prasad, Vibhu; Hensel, Zach; Bartenschlager, Ralf; Chlanda, PetrFunding Information: We thank the Infectious Diseases Imaging Platform (IDIP) at the Center for Integrative Infectious Disease Research Heidelberg, the cryo-EM network at the Heidelberg University (HD-cryoNET) and Heidelberg University Electron Microscopy Core Facility for support and assistance. The authors gratefully acknowledge the data storage service SDS@hd supported by the Ministry of Science, Research, a...
On the value of preprints
Sarabipour, Sarvenaz; Debat, Humberto J.; Emmott, Edward; Burgess, Steven J.; Schwessinger, Benjamin; Hensel, ZachPeer-reviewed journal publication is the main means for academic researchers in the life sciences to create a permanent public record of their work. These publications are also the de facto currency for career progress, with a strong link between journal brand recognition and perceived value. The current peer-review process can lead to long delays between submission and publication, with cycles of rejection, re...
Cell fate potentials and switching kinetics uncovered in a classic bistable gen...
Fang, Xiaona; Liu, Qiong; Bohrer, Christopher; Hensel, Zach; Han, Wei; Wang, Jin; Xiao, JieBistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However, such a scenario has not been experimentally observed. Here by developing a new, dual single-molecule gene-expres...
A plasmid-based Escherichia coli gene expression system with cell-to-cell varia...
Hensel, ZachExperiments in synthetic biology and microbiology can benefit from protein expression systems with low cell-to-cell variability (noise) and expression levels precisely tunable across a useful dynamic range. Despite advances in understanding the molecular biology of microbial gene regulation, many experiments employ protein-expression systems exhibiting high noise and nearly all-or-none responses to induction. I...