9 documents found, page 1 of 1
Prognostic factors in patients with advanced differentiated thyroid cancer trea...
Treistman,Natalia; Nobre,Gabriela Maia; Tramontin,Mariana Yoshii; Silva,Gabriel Madeira Werberich da; Herchenhorn,Daniel; Araujo,Luiz Henrique de LimaABSTRACT Objective: The aim of this study was to describe the real-world experience multikinase inhibitors (MKI) in the treatment advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAIR) therapy. Subjects and methods: We reviewed the records of all patients with MKI-treated DTC from 2010 to 2018. Progression free survival (PFS), response rates (RR) and adverse events (AE) profiles...
Consensus on diagnosis and management of non-metastatic castration resistant pr...
Maluf,Fernando; Soares,Andrey; Avanço,Guilherme; Hada,Aline Lury; Cardoso,Ana Paula Garcia; Carneiro,Arie; Herchenhorn,DanielABSTRACT Background: Non-metastatic castration resistant prostate cancer (M0 CRPC) has seen important developments in drugs and diagnostic tools in the last two years. New hormonal agents have demonstrated improvement in metastasis free survival in M0 CRPC patients and have been approved by regulatory agencies in Brazil. Additionally, newer and more sensitive imaging tools are able to detect metastasis earlier ...
Second brazilian consensus on the treatment of advanced prostate cancer: a SBOC...
Sasse,Andre Deeke; Reis,Rodolfo Borges dos; Nogueira,Lucas Mendes; Maluf,Fernando Cotait; Herchenhorn,Daniel; Smaletz,Oren; Lima,Volney SoaresABSTRACT Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths. In Brazil, it is likewise the second most common cancer among men, second only to non-melanoma skin cancers. The aim of this consensus is to align different opinions and interpretations of the medical literature in a practical and patient-oriented approach. The first Brazilian Consensus on the Treatment of Ad...
Impact of 68GA-PSMA PET / CT on treatment of patients with recurrent / metastat...
Mattiolli,Aline B.; Santos,Allan; Vicente,Andreia; Queiroz,Marcelo; Bastos,Diogo; Herchenhorn,Daniel; Srougi,Miguel; Peixoto,Fabio A.; Morikawa,LisaABSTRACT Purpose: The purpose of our study was to evaluate the clinical impact of 68Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer. Materials and Methods: We retrospectively evaluated 125 prostate cancer patients submitted to the 68Ga-PSMA PET / CT due to biochemical recurrence. The parameters age, Gleason score, PSA levels, and the highest SUVmax were correlated to potential treat...
First brazilian consensus of advanced prostate cancer: recommendations for clin...
Sasse,Andre Deeke; Wiermann,Evanius Garcia; Herchenhorn,Daniel; Bastos,Diogo Assed; Schutz,Fabio A.; Maluf,Fernando Cotait; Coura Filho,GeorgeABSTRACT Introduction Prostate cancer still represents a major cause of morbidity, and still about 20% of men with the disease are diagnosed or will progress to the advanced stage without the possibility of curative treatment. Despite the recent advances in scientific and technological knowledge and the availability of new therapies, there is still considerable heterogeneity in the therapeutic approaches for me...
Sunitinib treatment in patients with advanced renal cell cancer: the Brazilian ...
Coelho,Rafael Corrêa; Reinert,Tomás; Campos,Franz; Peixoto,Fábio Affonso; Andrade,Carlos Augusto de; Castro,Thalita; Herchenhorn,DanielABSTRACT Purpose: The aim of this study was to assess the impact of sunitinib treatment in a non-screened group of patients with metastatic renal cell cancer (mRCC) treated by the Brazilian Unified Health System (SUS) at a single reference institution. Material and Methods: Retrospective cohort study, which evaluated patients with mRCC who received sunitinib between May 2010 and December 2013. Results: Fifty-ei...
Tumor estromal gastrointestinal: análise de 146 casos do centro de referência d...
Linhares,Eduardo; Gonçalves,Rinaldo; Valadão,Marcus; Vilhena,Bruno; Herchenhorn,Daniel; Romano,Sergio; Ferreira,Maria Aparecida; Ferreira,Carlos GilOBJETIVO: Avaliar os resultados do tratamento de GIST no INCA. MÉTODOS: Análise retrospectiva de todos os casos de GIST tratados no INCA no período de 1997 a 2009. RESULTADOS: Analisamos 146 pacientes, com média de idade de 44,5 anos e predomínio do sexo feminino. O principal sintoma foi dor abdominal. Tivemos ocorrência de segundo primário em 22% dos casos e na imuno-histoquímica, 92% foram positivos para CD11...
Phase II trial of neoadjuvant gemcitabine and cisplatin in patients with resect...
Herchenhorn,Daniel; Dienstmann,Rodrigo; Peixoto,Fabio A.; Campos,Franz S. de; Santos,Valdelice O.; Moreira,Denise M.; Cardoso,Hedilene; Small,Isabele A.OBJECTIVES: Gemcitabine and cisplatin (GC) is an active combination in the treatment of metastatic bladder cancer. We have prospectively analyzed the efficacy and tolerability of GC as neoadjuvant treatment of invasive bladder cancer MATERIALS AND METHODS: In this single-institution phase II trial, patients with muscle-invasive transitional cell carcinoma received three cycles of gemcitabine 1200 mg/m² on days ...
Advances in radiochemotherapy in the treatment of head and neck cancer
Herchenhorn,Daniel; Dias,Fernando LuizNew advances are being incorporated into the radiochemotherapy treatment of squamous cell carcinoma of the head and neck. Although the overall prognosis is poor in advanced stages, the possibility of incorporating combined protocols of chemotherapy and radiotherapy for organ preservation or for palliation in cases of recurrent/locally advanced stages that are not good surgical candidates must not be forgotten. ...