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The association between dietary fiber intake and gastric cancer: a pooled analy...

Collatuzzo, G; Cortez Lainez, J; Pelucchi, C; Negri, E; Bonzi, R; Palli, D; Ferraroni, M; Zhang, ZF; Yu, GP; Lunet, N; Morais, S; López-Carrillo, L

"Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietar...


The protective effect of dietary folate intake on gastric cancer is modified by...

Gonzalez-Palacios, S; Compañ-Gabucio, LM; Torres-Collado, L; Oncina-Canovas, A; García-de-la-Hera, M; Collatuzzo, G; Negri, E; Pelucchi, C; Rota, M

Dietary folate intake has been identified as a potentially modifiable factor of gastric cancer (GC) risk, although the evidence is still inconsistent. We evaluate the association between dietary folate intake and the risk of GC as well as the potential modification effect of alcohol consumption. We pooled data for 2829 histologically confirmed GC cases and 8141 controls from 11 case–control studies from the int...


Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP ...

Collatuzzo, G; Negri, E; Pelucchi, C; Bonzi, R; Turati, F; Rabkin, CS; Liao, LM; Sinha, R; Palli, D; Ferraroni, M; López-Carrillo, L; Lunet, N

Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC an...


Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case...

Morais, S; Peleteiro, B; Araújo, N; Malekzadeh, R; Ye, W; Plymoth, A; Tsugane, S; Hidaka, A; Hamada, GS; López-Carrillo, L; Zaridze, D; Maximovich, D

Background: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection. We estimated the proportion of HpNGC, using different criteria to define infection status, and compared...


Coffee consumption and gastric cancer: A pooled analysis from the Stomach cance...

Martimianaki, G; Bertuccio, P; Alicandro, G; Pelucchi, C; Bravi, F; Carioli, G; Bonzi, R; Rabkin, CS; Liao, LM; Sinha, R; Johnson, K; Hu, J; Palli, D

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals ...


Exploring the interactions between Helicobacter pylori (Hp) infection and other...

Collatuzzo, G; Pelucchi, C; Negri, E; López-Carrillo, L; Tsugane, S; Hidaka, A; Shigueaki Hamada G; Hernández-Ramírez, RU; López-Cervantes, M

Helicobacter pylori (Hp) is crucial in gastric carcinogenesis, but infection alone is not a sufficient cause, and the interaction between Hp infection and other risk factors has not been adequately studied. We conducted a pooled analysis of seven case-control studies from the Stomach cancer Pooling (StoP) Project, comprising 1377 cases and 2470 controls, to explore the interaction among Hp infection and tobacco...


Fruits and vegetables intake and gastric cancer risk: A pooled analysis within ...

Ferro, A; Costa, AR; Morais, S; Bertuccio, P; Rota, M; Pelucchi, C; Hu, J; Johnson, KC; Zhang, ZF; Palli, D; Ferraroni, M; Yu, GP; Bonzi, R

A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with...


Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Poo...

Vitelli-Storelli, F; Rossi, M; Pelucchi, C; Rota, M; Palli, D; Ferraroni, M; Lunet, N; Morais, S; López-Carrillo, L; Zaridze, DG; Maximovich, D

Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six co...


Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) pro...

Ferro, A; Rosato, V; Rota, M; Costa, AR; Morais, S; Pelucchi, C; Johnson, KC; Hu, J; Palli, D; Ferraroni, M; Zhang, ZF; Bonzi, R; Yu, GP; Peleteiro, B

The consumption of processed meat has been associated with noncardia gastric cancer, but evidence regarding a possible role of red meat is more limited. Our study aims to quantify the association between meat consumption, namely white, red and processed meat, and the risk of gastric cancer, through individual participant data meta-analysis of studies participating in the “Stomach cancer Pooling (StoP) Project”....


Education and gastric cancer risk-An individual participant data meta-analysis ...

Rota, M; Alicandro, G; Pelucchi, C; Bonzi, R; Bertuccio, P; Hu, J; Zhang, ZF; Johnson, KC; Palli, D; Ferraroni, M; Yu, GP; Galeone, C; López-Carrillo, L

Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the “Stomach cancer Pooling (StoP) Project”. Educational level and household income were used as proxies for the SEP. We estimated pooled odds ratios...


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