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Use of statins and the risk of dementia and mild cognitive impairment: a system...

Chu, Che-Sheng; Tseng, Ping-Tao; Stubbs, Brendon; Chen, Tien-Yu; Tang, Chia-Hung; Li, Dian-Jeng; Yang, Wei-Cheng; Chen, Yen-Wen; Wu, Ching-Kuan

We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalys...

Date: 2018   |   Origin: Oasisbr

Peripheral cytokine and chemokine alterations in depression : a meta-analysis o...

Köhler, Cristiano A.; Freitas, Thiago H.; Maes, Michael; Andrade, Nayanna Q. de; Liu, Celina S.; Fernandes, Brisa S.; Stubbs, Brendon; Solmi, M.

Objective: To conduct a systematic revie w and meta -analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD ) compared to healthy controls (HCs). Method: The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were estimated wi th random-effects mod els. Result: Eighty-two studies comprising 3212 participants ...

Date: 2017   |   Origin: Oasisbr

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