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Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a ...
van Maurik, Ingrid S.; Vos, Stephanie J.; Bos, Isabelle; Bouwman, Femke H.; Teunissen, Charlotte E.; Scheitens, Philip; Barkhof, Frederik; Frolich, LutzBackground Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods In this modelling study, we included people with mild cognitive impairment (MCI) from ...
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE) : a...
van Maurik, Ingrid S; Vos, Stephanie J.; Bos, Isabelle; Bouwman, Femke H; Teunissen, Charlotte E.; Scheltens, Philip; Barkhof, Frederik; Frolich, LutzBackground: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods: In this modelling study, we included people with mild cognitive impairment (MCI) fro...
The frequency and influence of dementia risk factors in prodromal Alzheimer's d...
Bos, Isabelle; Vos, Stephanie J.; Frölich, Lutz; Kornhuber, Johannes; Wiltfang, Jens; Maier, Wolfgang; Peters, Oliver; Rüther, EckhartWe investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and ...
Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-...
Leitão, Maria João; Baldeiras, Inês; Herukka, Sanna-Kaisa; Pikkarainen, Maria; Leinonen, Ville; Simonsen, Anja Hviid; Perret-Liaudet, ArmandIntroduction: Core cerebrospinal fluid (CSF) biomarkers – Aβ42, Tau, and phosphorylated Tau (pTau) – have been recently incorporated in the revised criteria for Alzheimer’s disease (AD). However, their widespread clinical application lacks standardization. Preanalytical sample handling and storage play an important role in the reliable measurement of these biomarkers across laboratories. Aim: In this study, we ...
Prevalence of cerebral amyloid pathology in persons without dementia
Jansen, Willemijn J.; Ossenkoppele, Rik; Knol, Dirk L.; Tijms, Betty M.; Scheltens, Philip; Verhey, Frans R. J.; Visser, Pieter Jelle; Aalten, PaulineImportance: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. Objective: To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as meas...
Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairmen...
Vos, Stephanie J. B.; Verhey, Frans; Frölich, Lutz; Kornhuber, Johannes; Wiltfang, Jens; Maier, Wolfgang; Peters, Oliver; Rüther, Eckart; Nobili, FlavioThree sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognit...