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Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TO...

Houdová, Dominika; Soto, Juan; Castro, Rita; Rodrigues, João; Soledad Pino-González, Mª; Petković, Marijana; Bandosz, Teresa J; Algarra, Manuel

A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary sy...


Lipid biosignature of breast cancer tissues by matrix-assisted laser desorption...

Silva, Catarina L.; Perestrelo, Rosa; Sousa-Ferreira, Ivo; Capelinha, Filipa; Câmara, José S.; Petković, Marijana

Purpose One of the hallmarks of cancer cells is the demand of supply for the synthesis of new membranes involved in cell proliferation and lipids have an important role in cellular structure, signaling pathways and progression of cancer. In this sense, lipid studies have become an essential tool allowing the establishment of signatures associated with breast cancer (BC). In this regard, some metabolic processes...


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