24 documents found, page 1 of 3

Lung Cancer Screening in Portugal: A PULMONALE Pilot Project

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Rastreio do Cancro do Pulmão, para quando?

Implementation of a Pilot Study to Analyze Circulating Tumor DNA in Early-Stage...

Introduction: Liquid biopsies based on plasma circulating tumour deoxyribonucleic acid (ctDNA) have shown promise in monitoring lung cancer evolution. The expression of ctDNA across time, its relationship with clinicopathological parameters and its association with lung cancer progression through imaging allow us to weigh how useful ctDNA could be in monitoring surgically resectable lung cancer. The aim of this...

Patient Blood Management – is its application possible in oncology?

Patient blood management (PBM) is a safe approach aiming to improve a patient’s medical and surgical management in ways that boost and conserve their own blood. Approximately 32% to 60% of oncology patients have iron deficiency – the majority of whom are anaemic – therefore, it is important to discuss strategies to avoid excessive blood usage and the reduction of tumour progression and cancer recurrence. In thi...

T790M-EGFR mutation frequency in advanced NSCLC patients on progression from a ...

Medical decision in COPD: the evidence-based history

Randomized controlled trials together with systematic reviews and meta-analyses have been the cornerstone of clinical research. Some studies, because of the size of the sample, the use of randomization and well-defined measurements, the participation of multiple institutions, or long-term follow-up, are able to give a significant level of evidence. We chronologically describe and comment on a group of trials on...

Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutat...

 Osimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Clinical outcomes and molecular results from re-biopsie...

Pneumonia mortality, comorbidities matter?

Pneumonia remains one of the most important causes of mortality. In Portugal, it is the first cause of respiratory death, excluding lung cancer. This is a retrospective cohort study designed to seek for explanations, identifying the characteristics of patients and measure the impact of each one of them on the risk of dying from pneumonia. We analyzed demographic and clinical data of all patients (pts) with 18 y...

Characterisation of morbidity in a COPD hospital cohort

Objectives To characterise the morbidity of COPD out-patients based on symptoms, acute exacerbations, FEV1 and comorbidities, and to explore the association between different patients’ characteristics such as social, demographic, clinical history or exposure. Methods Stable COPD outpatients over 40 years old diagnosed according to GOLD criteria were included consecutively; the exclusion criteria were only refus...

Teaching inhalation technique in COPD outpatients: Can a sustained improvement ...