D?Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil.; D?Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / University of Campinas. Institute of Biology. Department of Biochemistry and Tissue Biology. Campinas, SP, Brazil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Insti...
Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a member of the Flaviviridae family. Its worldwide incidence is now a major health problem, with 2.5 billion people living in risk areas. In this review, we integrate the structural rearrangements of each viral protein and their functions in all the steps of virus entry into the host cells. We describe in detail the putative rec...