7 documents found, page 1 of 1
Relationship between short and long-term glycemic variability and oxidative str...
Valente,Tatiana; Valente,Fernando; Lucchesi,Maria Beatriz Bastos; Punaro,Giovana Rita; Mouro,Margaret Gori; Gabbay,Monica Andrade LimaABSTRACT Objectives: The purpose of this study was to investigate the heterogeneity of the association between glycemic variability and oxidative stress markers in T1DM patients under daily life insulin treatment. Subjects and methods: We studied, in a cross-sectional analysis, 76 T1DM patients without clinical chronic diabetes complications and 22 healthy individuals. Were evaluated the short-term glycemic var...
P2X7 receptor-nitric oxide interaction mediates apoptosis in mouse immortalized...
Fernandes,Thamires de Oliveira; Rodrigues,Adelson Marçal; Punaro,Giovana Rita; Lima,Deyse Yorgos de; Higa,Elisa Mieko SuemitsuAbstract Introduction: Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia that leads to diabetic nephropathy (DN). We showed that P2X7, a purinergic receptor, was highly expressed in DM; however, when oxidative stress was controlled, renal NO recovered, and the activation of this receptor remained significantly reduced. The aim of this study was to assess the influence of NO on the P2X7 ...
Cbfa1 expression in vascular smooth muscle cells may be elevated by increased n...
Gloria,Maria Aparecida da; Mouro,Margaret Gori; Geraldini,Simone; Higa,Elisa Mieko Suemitsu; Carvalho,Aluizio BarbosaABSTRACT Introduction: Vascular calcification is a common complication of chronic kidney disease. Osteoblast differentiation factor (Cbfa1) is present in histologic sections of arteries from patients with end-stage renal disease. Vascular smooth muscle cells (VSMC) can dedifferentiate to osteoblast-like cells, possibly by up-regulation of Cbfa1. There is evidence that the production of nitric oxide (NO) may hav...
Nitric oxide levels in cochlear fluids of guinea pig
Yonamine,Fernando Kaoru; Onishi,Ektor Tsuneo; Mouro,Margareth Gori; Higa,Elisa Mieko Suemitsu; Cruz,Oswaldo Laércio MendonçaPURPOSE: To describe a technique to obtain guinea pigs cochlear fluids and measure nitric oxide (NO) concentration. METHODS: Six guinea pigs were used and sacrificed. The cochlear fluids collected for measurement of NO, performed by chemiluminescence (NOA 280). RESULTS: Through the chemiluminescence was possible to analyze the concentration of NO in cochlear fluids obtained. Average levels of nitric oxide from ...
Depressive symptoms in patients with acute coronary syndrome
Mello,Aline Pardo de; Carvalho,Antonio Carlos de Camargo; Higa,Elisa Mieko SuemitsuABSTRACT Objective: To trace an epidemiological profile, to verify presence of depressive symptoms in patients with previous diagnosis of acute coronary syndrome and to identify factors that contribute to maintenance of depressive symptoms in the sample. Methods:A cross-section study carried out at the Cardiology Outpatients Clinics of Universidade Federal de São Paulo. An instrument prepared by the authors was...
Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensi...
Varella,Pedro Paulo Vasconcellos; Santiago,Joselita Ferreira Carvalho; Carrete Jr.,Henrique; Higa,Elisa Mieko Suemitsu; Yacubian,Elza Márcia TargasWe investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of pat...
Suplementação proteica não aumenta a concentração plasmática de óxido nítrico e...
Moraes,Milton Rocha de; Aoki,Marcelo Saldanha; Araújo,Ronaldo de Carvalho; Higa,Elisa Mieko Suemitsu; Mouro,Margaret Gori; Bacurau,Reury Frank PereiraSuplementos nutricionais, supostamente, capazes de potencializar a produção endógena de óxido nítrico (NO) têm experimentado crescente popularidade entre os indivíduos fisicamente ativos. Diante da carência de informações sobre o assunto, o objetivo do presente estudo foi avaliar o efeito de um suplemento comercial à base de proteínas e aminoácidos sobre a produção endógena de NO. MÉTODOS: A amostra foi constit...