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Ionic liquid-based nanoemulsion as a promising strategy to enhance the bioacces...

Sousa, Vítor; Lüdtke, Fernanda Luisa; Hijo, Ariel A. C. Toledo; Loureiro, Luís; Dias, Oscar; Vicente, A. A.; Pinheiro, A. C.; Geada, Pedro

Dunaliella salina is a unicellular halophile green microalga that presents the capacity to accumulate high amounts of β-carotene, a bioactive compound widely recognized by its health benefits. To fulfil its biological functions, however, β-carotene needs to be bioaccessible, which is challenging as its bioaccessibility is typically low. A promising strategy to overcome β-carotene's low bioaccessibility is its e...


Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to prod...

Vardanega, Renata; Lüdtke, Fernanda Luisa; Loureiro, Luís Carlos Sá; Hijo, Ariel A. C. Toledo; Martins, Joana T.; Pinheiro, A. C.; Vicente, A. A.

The emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid-based nanosystems developed to enhance the bioaccessibility of cannabidiol (CBD) was investigated. The IL (cholinium oleate) was evaluated at concentrations of 1 % and 2 % to produce nanoemulsions (NE-IL) and nanostructured lipid carriers (NLC-IL) loaded with CBD. The IL concentration of 1 % demonstrated to be sufficient to produce ...


Recovery and encapsulation of Dunaliella salina -carotene through a novel susta...

Sousa, Vítor; Hijo, Ariel A. C. Toledo; Lüdtke, Fernanda Luisa; Vicente, A. A.; Dias, Oscar; Geada, Pedro Miguel Macedo

Dunaliella salina is a promising source of -carotene, widely employed in the food industry. This study aimed to evaluate the sequential application of the Ionic Liquid (IL) cholinium oleate as an extraction solvent for D. salina -carotene recovery and, sequentially, as emulsifier for emulsion-based products obtained therefrom. The IL was evaluated regarding its ability to permeabilize the cells and recover -car...


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