2 documents found, page 1 of 1
Resolving the ancestry of Austronesian-speaking populations
Soares, P; Trejaut, JA; Rito, T; Cavadas, B; Hill, C; Eng, KK; Mormina, M; Brandão, A; Fraser, RM; Wang, T-Y; Loo, J-H; Snell, C; Ko, T-M; Amorim, AThere are two very different interpretations of the prehistory of Island Southeast Asia (ISEA), with genetic evidence invoked in support of both. The "out-of-Taiwan" model proposes a major Late Holocene expansion of Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Late Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic...
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvat...
Garate, Z; Quintana-Bustamante, O; Crane, AM; Olivier, E; Poirot, L; Galetto, R; Kosinski, P; Hill, C; Kung, C; Agirre, X; Orman, I; Cerrato, LPyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impair ATP production in erythrocytes. We generated PKD induced pluripotent stem cells (PKDiPSCs) from peripheral blood mononuclear cells (PB-MNCs) of PKD patients by no...