4 documents found, page 1 of 1
Transcriptome Analysis Describing New Immunity and Defense Genes in Peripheral ...
Teixeira, Vitor Hugo; Olaso, Robert; Martin-Magniette, Marie-Laure; Lasbleiz, Sandra; Jacq, Laurent; Oliveira, Catarina Resende; Hilliquin, PascalBackground: Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study was to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular...
Association and Expression Study of PRKCH Gene in a French Caucasian Population...
Teixeira, Vitor; Jacq, Laurent; Moore, Jeoiakim; Lasbleiz, Sandra; Hilliquin, Pascal; Oliveira, Catarina Resende; Cornelis, FrançoisWe study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis. One hundred French Caucasian rheumatoid arthritis trio families were genotyped. Relative quantification of protein kinase C, eta mRNA expression was performed from whole blood in 24 unrelated rheumatoid arthritis patients and in 16 healthy controls. Our resu...
The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the Eur...
Jacq, Laurent; Garnier, Sophie; Dieudé, Philippe; Michou, Laëtitia; Pierlot, Céline; Migliorini, Paola; Balsa, Alejandro; Westhovens, RenéThe integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide p...
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French...
Jacq, Laurent; Teixeira, Vitor; Garnier, Sophie; Michou, Laëtitia; Dieudé, Philippe; Rocha, Dominique; Pierlot, Céline; Lemaire, IsabelleAbstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three sing...