10 documents found, page 1 of 1
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling, Sustaining Proliferation,...
Lemos, Isabel; Freitas-Dias, Catarina; Hipólito, Ana; JS, Ramalho; Carteni, Fabrizio; G Goncalves, Luis; MAZZOLENI, Stefano; Serpa, JacintaFunding Information: This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal, with equipment funded by FCT, project AAC 01/SAICT/2016. Funding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/202...
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcin...
Lemos, Isabel; Freitas-Dias, Catarina; Hipólito, Ana; JS, Ramalho; Carteni, Fabrizio; G Goncalves, Luis; Mazzoleni, Stefano; Serpa, JacintaFunding Information: This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal, with equipment funded by FCT, project AAC 01/SAICT/2016. Funding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/202...
BRD9 status is a major contributor for cysteine metabolic remodeling through MS...
Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, DuartePublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...
H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management to...
Hipólito, Ana; Mendes, Cindy; Martins, Filipa; Lemos, Isabel; Francisco, Inês; Cunha, Fernando; Almodôvar, Teresa; Albuquerque, CristinaFunding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020), and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). The study was partially supported by a Merck KGaA, Darmstad...
Metabolic profiling and combined therapeutic strategies unveil the cytotoxic po...
Mendes, Cindy; Lemos, Isabel; Hipólito, Ana; Abreu, Bruna; Freitas-Dias, Catarina; Martins, Filipa; Pires, Rita F.; Barros, Hélio; Bonifácio, Vasco D.B.Funding Information: The institutions are funded by Fundac\u00B8 \u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health [grant numbers UIDB/04462/2020 and UIDP/04462/2020], to MOSTMICRO-ITQB [grant numbers UIDB/04612/2020 and UIDP/04612/2020] and the Associated Laboratory LS4FUTURE [grant number LA/P/...
A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, ...
Lopes-Coelho, Filipa; Martins, Filipa; Hipólito, Ana; V Conde, Silvia; SA, Pereira; Gonçalves, Luís G; Serpa, JacintaFunding: The institutions are funded by Fundação para a Ciência e Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020), and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). Filipa Lopes-Coelho’s fellowship was funded by FCT (PD/BD/128337/2017). ...
The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism
Lopes-Coelho, Filipa; Martins, Filipa; Hipólito, Ana; Mendes, Cindy; Sequeira, Catarina O.; Pires, Rita F.; Almeida, António M.; Bonifácio, Vasco D.B.Funding: The project was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e Ciência, through national funds. We also acknowledge funding from FCT-MCTES through the project DREAM—PTDC/MEC-ONC/29327/2017. FL-C PhD fellowship was funded by FCT (PD/BD/128337/2017).; The activation of endothelial cells...
Molecular and Metabolic Reprogramming
Hipólito, Ana; Martins, Filipa; Mendes, Cindy; Lopes-Coelho, Filipa; Serpa, JacintaFunding: The research group was funded by IPOLFG EPE and by iNOVA4Health (UID/Multi/04462/2019) a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/ Ministério da Educação e Ciência, through national funds. All the fellowships were funded by FCT: AH (SFRH/BD/148441/ 2019), FM (2020.04780.BD), CM (2020.06956.BD), FL-C (PD/ BD/128337/2017).; Metastasis is a major hurdle to the efficient ...
Cysteine Aminotransferase (CAT)
Hipólito, Ana; Nunes, Sofia C.; Vicente, João B.; Serpa, JacintaMetabolic remodeling is a critical skill of malignant cells, allowing their survival and spread. The metabolic dynamics and adaptation capacity of cancer cells allow them to escape from damaging stimuli, including breakage or cross-links in DNA strands and increased reactive oxygen species (ROS) levels, promoting resistance to currently available therapies, such as alkylating or oxidative agents. Therefore, it ...
Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment ...
Santos, Inês; Ramos, Cristiano; Mendes, Cindy; Sequeira, Catarina O.; Tomé, Catarina S.; Fernandes, Dalila G.H.; Mota, Pedro; Pires, Rita F.The research was funded by iNOVA4Health UID/Multi/04462, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência (FCT-MCTES), through national funds, and co-funded by FEDER under the PT2020 Partnership Agreement. We also acknowledge funding from FCT-MCTES through project DREAM PTDC/MEC-ONC/29327/2017.; Ovarian cancer is the main cause of death from gynecological ...