5 documents found, page 1 of 1
The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymo...
Souza,Karla Simone Costa de; Ururahy,Marcela Abbott Galvão; Oliveira,Yonara Monique da Costa; Loureiro,Melina Bezerra; Silva,Heglayne Pereira Vital daABSTRACT Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and methods: A total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determi...
III Diretrizes para Tuberculose da Sociedade Brasileira de Pneumologia e Tisiol...
Conde,Marcus Barreto; Melo,Fernando Augusto Fiuza de; Marques,Ana Maria Campos; Cardoso,Ninarosa Calzavara; Pinheiro,Valeria Goes FerreiraDiariamente novos artigos científicos sobre tuberculose (TB) são publicados em todo mundo. No entanto, é difícil para o profissional sobrecarregado na rotina de trabalho acompanhar a literatura e discernir o que pode e deve ser aplicado na prática diária juntos aos pacientes com TB. A proposta das "III Diretrizes para TB da Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)" é revisar de forma crítica o qu...
A novel 3-base deletion (IVS3+2_4delTGG) of the hydroxymethylbilane synthase ge...
Ribeiro,Georgina Severo; Marchiori,Paulo Eurípedes; Hirata,Mário Hiroyuki; Rebecchi,Ivanise; Ozaki,Adriana Natsue; Nagai,Maria AparecidaAcute intermittent porphyria (AIP, OMIM 176000) is an autosomal dominant metabolic disease caused by mutations in the gene encoding hydroxymethylbilane synthase (HMBS; EC 4.3.1.8; formely named porphobilinogen deaminase, PBGD), mapped to chromosome 11q23.3. We describe a novel mutation of the HMBS gene, a de novo 3-base deletion in the splicing donor site of intron 3 (IVS3+2_4delTGG) in a woman affected by AIP....
DNA extraction from human saliva deposited on skin and its use in forensic iden...
Anzai-Kanto,Evelyn; Hirata,Mário Hiroyuki; Hirata,Rosario Dominguez Crespo; Nunes,Fabio Daumas; Melani,Rodolfo Francisco HaltenhoffSaliva is usually deposited in bite marks found in many homicides, assault and other criminal cases. In the present study, saliva obtained from volunteers was deposited on skin and recovered for DNA extraction and typing in order to evaluate its usefulness for practical case investigation and discuss the contribution of forensic dentistry to saliva DNA typing. Twenty saliva samples were colleted from different ...
PCR in the diagnosis of cutaneous tuberculosis
Ogusku,Mauricio Morishi; Sadahiro,Aya; Hirata,Mário Hiroyuki; Hirata,Rosário D. C.; Zaitz,Clarisse; Salem,Júlia IgnezSeeking to improve the laboratory diagnosis of Cutaneous Tuberculosis, a study was carried out on the application of PCR technique in macerated, decontaminated(with 4% H2SO4 for elimination of normal microbiot), neutralized (with 4% NaOH)biopsies tissues samples stored at -20ºC. Of the 37 samples submitted for study, 16.22% were positive by microscopy for acid-fast bacilli (concentrated method) and in 43.24% th...