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Somatic CAG repeat expansion in blood associates with biomarkers of neurodegene...
Scahill, Rachael I.; Farag, Mena; Murphy, Michael J.; Hobbs, Nicola Z.; Leocadi, Michela; Langley, Christelle; Knights, Harry; Ciosi, Marc; Fayer, KateHuntington's disease (HD) is an autosomal dominant neurodegenerative disease with the age at which characteristic symptoms manifest strongly influenced by inherited HTT CAG length. Somatic CAG expansion occurs throughout life and understanding the impact of somatic expansion on neurodegeneration is key to developing therapeutic targets. In 57 HD gene expanded (HDGE) individuals, ~23 years before their predicted...
Data: 2025
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Origem: Repositório da Universidade de Lisboa