3 documents found, page 1 of 1
Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibioti...
Leitao, MM; Vieira, TF; Sousa, SF; Fernanda Borges; Simoes, M; Anabela Borges; Simões MQuorum sensing (QS) has a central role in biofilm lifestyle and antimicrobial resistance, and disrupting these signaling pathways is a promising strategy to control bacterial pathogenicity and virulence. In this study, the efficacy of three structurally related benzaldehydes (4-hydroxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde (vanillin) and 4-hydroxy-3,5-dimethoxybenzaldehyde (syringaldehyde)) in disrupting...
Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents a...
Vieira, TF; Leitao, MM; Cerqueira, NMFSA; Sousa, SF; Anabela Borges; Simoes, M; Simões MAims Drug repurposing is an attractive strategy to control biofilm-related infectious diseases. In this study, two drugs (montelukast and cefoperazone) with well-established therapeutic applications were tested on Pseudomonas aeruginosa quorum sensing (QS) inhibition and biofilm control.Methods and results The activity of montelukast and cefoperazone was evaluated for Pqs signal inhibition, pyocyanin synthesis,...
Photodynamic activation of phytochemical-antibiotic combinations for combatting...
Gonçalves, ASC; Leitao, MM; Fernandes, JR; Saavedra, MJ; Pereira, C; Simoes, M; Anabela Borges; Simões MStaphylococcus aureus is characterized by its high resistance to conventional antibiotics, particularly methicillinresistant (MRSA) strains, making it a predominant pathogen in acute and chronic wound infections. The persistence of acute S. aureus wound infections poses a threat by increasing the incidence of their chronicity. This study investigated the potential of photodynamic activation using phytochemical-...