4 documents found, page 1 of 1
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Diso...
Mullins, Niamh; Kang, JooEun; Campos, Adrian I; Coleman, Jonathan R I; Edwards, Alexis C; Galfalvy, Hanga; Levey, Daniel F; Lori, AdrianaBackground: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) c...
Common variants in Alzheimer's disease and risk stratification by polygenic ris...
de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Pedersen, Nancy L.; Stringa, NajadaGenetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Her...
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...
Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells
Nokhbehsaim, Marjan; Eick, Sigrun; Nogueira, Andressa Vilas Boas [UNESP]; Hoffmann, Per; Herms, Stefan; Fröhlich, Holger; Jepsen, Søren; Jäger, AndreasSubmitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:30:44Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:43:33Z : No. of bitstreams: 1 2-s2.0-84884277332.pdf: 2996614 bytes, checksum: 24ac32304f7ee002eb509d1f7644b0c5 (MD5); Made available in DSpace on 2014-05-27T11:30:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-23; Periodontitis is an inflammatory d...