3 documents found, page 1 of 1
Arterial stiffness and influences of the metabolic syndrome: a cross-countries ...
Scuteri, Angelo; Cunha, Pedro Guimarães; Rosei, E. Agabiti; Bekaert, Sofie; Cockcrofti, John R.; Cotter, Jorge; Cucca, Francesco; De Buyzere, Marc L.Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether spec...
Association between alcohol and cardiovascular disease : Mendelian randomisatio...
Holmes, M. V.; Dale, C. E.; Zuccolo, L.; Silverwood, R. J.; Guo, Y.; Ye, Z.; Prieto-Merino, D.; Dehghan, A.; Trompet, S.; Wong, A.; Cavadino, A.Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 ...
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE coll...
Traylor, M.; Farrall, M.; Holliday, E.G.; Sudlow, C.; Hopewell, J.C.; Cheng, Y.C.; Fornage, M.; Ikram, M.A.; Malik, R.; Bevan, S.; Thorsteinsdottir, U.Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.