13 documents found, page 1 of 2
Influence of cyclosporin a therapy on bone healing around titanium implants: A ...
Sakakura, Celso E.; Margonar, Rogério; Holzhausen, Marinella; Nociti Jr., Francisco H.; Alba, Rodolfo Candia; Marcantonio Jr., ElcioMade available in DSpace on 2022-04-29T08:42:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-07-01; Background: Immunosuppressive agents may induce severe changes on bone metabolism. The purpose of the present study was to evaluate the influence of the administration of cyclosporin A (CsA) on the bone tissue around titanium implants. Methods: Eighteen New Zealand rabbits were randomly divided into 2 g...
Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in...
Holzhausen, Marinella; Palomari Spolidorio, Denise M.; Muscará, Marcelo Nicolás; Hebling, Josimery; Spolidorio, Luis CarlosMade available in DSpace on 2022-04-29T08:42:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-06-01; Background: The purpose of the present study was to evaluate the effect of a potent selective cyclooxygenase-2 (COX-2) inhibitor, etoricoxib, on the prevention of alveolar bone loss in experimental periodontitis induced in rats. Methods: Ninety Wistar rats were separated into three experimental groups. ...
Protease-activated receptor-2 activation: A major role in the pathogenesis of P...
Holzhausen, Marinella; Spolidorio, Luis Carlos; Ellen, Richard P.; Jobin, Marie-Claude; Steinhoff, Martin; Andrade-Gordon, Patricia; Vergnolle, NathalieMade available in DSpace on 2022-04-29T08:43:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-01-01; We have investigated the specific contribution of protease-activated receptor-2 (PAR2) to host defense during Porphyromonas gingivalis infection. Culture supernatants from P. gingivalis strains 33277 and W50 provoked Ca2+ mobilization in cells transfected with PAR2 (PAR2-KNRK) and desensitized the subse...
Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in ...
Moro, Marcella G.; Oliveira, Marilia D. S.; Santana, Maria M.; de Jesus, Flavia N.; Feitosa, Karla; Teixeira, Simone A.; Franco, Gilson C. N.Made available in DSpace on 2021-06-25T10:53:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Background: Leukotrienes (LTs) participate in the process of tissue damage in periodontal disease by leukocyte chemotaxis and osteoclastic activation. The activation of Cysteinyl-LT receptor is associated with increased expression of proinflammatory molecules and osteoclastogenesis. However, its implica...
Effects of selective versus non- selective cox-2 inhibition on experimental per...
Moro, Marcella Goetz; Oliveira, Marilia Dantas Dos Santos; Oliveira, Leticia Rodrigues De; Teixeira, Simone Aparecida; Muscará, Marcelo NicolasMade available in DSpace on 2019-10-06T16:27:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-01. Added 1 bitstream(s) on 2019-10-09T18:35:23Z : No. of bitstreams: 1 S0103-64402019000200133.pdf: 378447 bytes, checksum: 12e2c861ff75906a1ed3660e6c05ac0c (MD5); In the present study we compared the effects of the selective COX-2 inhibitor etoricoxib with those of the classical non-selective NSAID diclof...
Nafamostat mesilate, a potent tryptase inhibitor, modulates periodontitis in rats
Holzhausen, Marinella; Balejo, Rodrigo D. P.; Lara, Guilherme M.; Cortelli, Sheila Cavalca; Saad, Wilson Abrao; Cortelli, José RobertoMade available in DSpace on 2019-09-12T16:53:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2011; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Previous reports have demonstrated increased tryptase-like proteolytic activity in the crevicular fluid of patients with periodontal disease. In the present study, we have investigated the effect of tryptase inhibition with nafamostat mesilate (NM...
Prevalence and distribution of serotype-specific genotypes of Aggregatibacter a...
Roman-Torres, Caio Vinícius Gonçalves; Aquino, Davi Romeiro; Cortelli, Sheila Cavalca; Franco, Gilson Cesar Nobre; Santos, Juliana Guimaraes dosMade available in DSpace on 2019-09-12T16:53:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2010; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Objective: Previous studies have suggested that Aggregatibacter actinomycetemcomitans is involved in the aetiology of aggressive periodontitis as well as chronic periodontitis. ...
Human beta-defensin 2 and protease activated receptor-2 expression in patients ...
Pereira, Alexandre Lustosa; Holzhausen, Marinella; Nobre Franco, Gilson Cesar; Cortelli, Sheila Cavalca; Cortelli, José RobertoMade available in DSpace on 2019-09-12T16:53:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2012; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Objetivo Alguns estudos anteriores mostraram que as gingipains, proteases semelhantes à tripsina produzidas por Porphyromonas gingivalis , regulam positivamente a expressão de mRNA da β defensina-2 humana (HBD-2) por meio do receptor-2 ativado por...
Porphyromonas Gingivalis is Associated With Protease-Activated Receptor-2 Upreg...
Fagundes, Jose Americo G.; Monoo, Leticia D.; Alves, Vanessa Tubero Euzebio; Pannuti, Claudio Mendes; Cortelli, Sheila Cavalca; Cortelli, José RobertoMade available in DSpace on 2019-09-12T16:56:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2011; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de Taubaté (Unitau); Background: We previously reported a higher expression of protease-activated receptor-2 (PAR(2)) together with higher interleukin (IL)-1 alpha, IL-6, IL-8, and tumor necrosis factor-alpha levels, total proteolytic...
Reduction of salivary arginine catabolic activity through periodontal therapy
Pereira, Alexandre L.; Cortelli, Sheila Cavalca; Aquino, Davi Romeiro; Franco, Gilson C. N.; Cogo, Karina; Rodrigues, Edson; Costa, Fernando de OliveiraMade available in DSpace on 2019-09-12T16:57:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2012; Objective: Salivary enzymes may be used to diagnose periodontal conditions. Salivary arginase activity (SAA) is related to susceptibility to bacterial infection. Therefore, the aim of this controlled interventional study was to determine the SAA before and after non-surgical periodontal therapy. Method and Ma...