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aPKC regulates apical constriction to prevent tissue rupture in the Drosophila ...
Osswald, M; Barros-Carvalho, A; Carmo, AM; Loyer, N; Gracio, PC; Sunkel, CE; Homem, CCF; Januschke, J; Morais-de-Sá, EApical-basal polarity is an essential epithelial trait controlled by the evolutionarily conserved PAR-aPKC polarity network. Dysregulation of polarity proteins disrupts tissue organization during development and in disease, but the underlying mechanisms are unclear due to the broad implications of polarity loss. Here, we uncover how Drosophila aPKC maintains epithelial architecture by directly observing tissue ...
Date: 2022
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Origin: Repositório Aberto da Universidade do Porto