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Mutational profle of Brazilian lung adenocarcinoma unveils association of EGFR ...
Leal, Letícia Ferro; Paula, Flávia Escremim de; De Marchi, Pedro; Viana, Luciano de Souza; Pinto, Gustavo Dix Junqueira; Carlos, Carolina DiasLung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicop...
Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString t...
Evangelista, Adriane F.; Zanon, Maicon F.; Carloni, Adriana C.; Paula, Flávia Escremim de; Morini, Mariana Andozia; Ferreira-Neto, MaressaBackground: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular techniques, such as NanoString nCounter, have been developed to detect ALK fusions with more accuracy and sensitivity. Methods: In the present study, we intend...